Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week

More from Latent Space: The AI Engineer Podcast

1. 

   10 Oct 2026 · 32 minNew

   Why AlphaFold Didn't Solve Protein Folding — Pushmeet Kohli, Google DeepMind & Sal Candido, Biohub

   From the Bitter Lesson of AI scaling to the unsolved mysteries of protein folding , Google DeepMind’s Pushmeet Kohli and Biohub’s Sal Candido are rethinking what it takes to build AI that truly understands biology. In this special panel moderated by Brandon Anderson , they explore why AlphaFold’s breakthrough was only the beginning , why scaling compute and data alone won’t solve biology, and how the next generation of AI models could transform our understanding of proteins, cells, and human disease. We go deep on the future of AI-driven biology : finding scaling laws in biological data, the…

2. 

   8 Oct 2026 · 1 hr 24 minNew

   Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk

   It’s hard to believe that Periodic was only launched last September : One year later, it is considered one of the pre-eminent AI scientist labs, with dizzying talent density and astonishing progress in the autonomous lab buildout: Most people are familiar with the standard credentials of Liam and Dogus , but we found an incredible “talent slope” while learning more about Periodic, where each successive employee seems more impressive than the last: From building AI systems that reason over noisy physical experiments to creating laboratories where every instrument can become intelligent,…

3. 

   2 Oct 2026 · 1 hr 41 min

   Academia is for Ambition — Alex Zhang, MIT

   Last call for regular tickets for AI Engineer NYC ! As an exclusive for Latent Space subscribers, the first 30 of you can take a 30% off code if it helps - for new tickets only, no refunds! See you in 2 weeks! While we tend to cover industry on the pod, every so often we celebrate a clearly emerging superstar PhD. In 2024 we featured Shunyu Yao , who went on to build Operator at OpenAI and is now Chief AI Scientist of Tencent . In 2025 we featured Jack Morris , who went on to cofound Engram at $600m and is now a leading voice on continual learning . This year we are proud to feature the work…

4. 

   29 Sep 2026 · 1 hr 32 min

   Claude Code’s Next Era — Thariq Shihipar, Anthropic

   We are excited to have Anthropic share their latest AI x Finance work at AI Engineer New York , coming up in 2 weeks! In case you’ve been under a rock, here’s a non-exhaustive list of what Anthropic has been shipping since closing the largest fundraise of all time in May at $47B ARR: * June: Launched Claude Tag and Sonnet 5 and Fable 5 * July: Opus 5 , /checkup . crossed $65B ARR * Last month: Fable/Mythos 5.1 , and EFS (upcoming pod) * IPO target $2T , end 2026 ARR estimated $100B * Cowork/chat merged before did * Claude Mods * Dario endorses the same Pacing the Frontier message cosigned by…

5. 

   25 Sep 2026 · 1 hr 21 min

   OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha

   From the earliest days of open-weight models to becoming the neutral routing layer for more than 10 million developers , OpenRouter is one of the clearest bets that the future of AI will be multi-model. In this episode, OpenRouter co-founder & CEO Alex Atallah, with AMP’s Anjney Midha returning with swyx to unpack how OpenRouter emerged from the first wave of Llama , Alpaca, Mistral, and Midjourney, why model diversity mattered before it was consensus, and how a company dismissed as “just a wrapper” became critical infrastructure for the AI ecosystem. We go deep on the product and…

6. 

   25 Sep 2026 · 1 hr 36 min

   Runway’s WorldPrompt and the Engineering of Real-Time Worlds

   Earlier this month, world model company Runway introduced GWM Worlds 2 , a research preview that “turns high-fidelity video and audio generation into real-time interactive simulation .” Runway calls this an “autoregressive diffusion” model; with autoregressive describing how it generates over time. One new feature in particular caught our eye: WorldPrompt , a proposed input format for specifying a generated world and the actions within it. It allows you to fix some aspects of a simulated environment — including the first frame — and then create a series of timestamped events . The events, or…

7. 

   23 Sep 2026 · 1 hr 32 min

   🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics)

   The OpenAI → Hugging Face attack has people asking “what else do we need to worry about?” and Anthropic’s filters flag two things: cyber-security and biology. The natural question is: what about bio-security, then? Clem Delangue argues that cyber-warfare defensive capabilities need to be open and to keep pace with frontier models’ attack capabilities Radical Numerics co-founder Eric Nguyen sat down with us and explained why the same models that increase biological capability can also keep defense from falling behind. Building a virus from scratch While he was at Stanford, Eric couldn’t get…

8. 

   22 Sep 2026 · 2 hr 1 min

   🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

   How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar , two textbook algorithms , two named asteroids, and an Erdos-Bacon number of 6. This was easily the most fun bio of all the guests we’ve read to date. And the result was an epic and fun chat covering Google’s Empirical Research Assistance (ERA), how AI can help battle climate change, and tons of great stories about the co-evolution of science and AI. John’s colleague Dave Bacon likes to tease John that his career has been defined by being…

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