#486 — Luck All the Way Down

More from Making Sense with Sam Harris

1. 

   11 Aug 2026 · 48 min

   #150 — The Map of Misunderstanding (From the Archive)

   From the archive: In this 2019 episode, Sam Harris speaks with Daniel Kahneman at the Beacon Theatre in NYC. They discuss the replication crisis in science, System 1 and System 2, where intuitions reliably fail, expert intuitions, the power of framing, moral illusions, anticipated regret, the asymmetry between threats and opportunities, the utility of worrying, removing obstacles to wanted behaviors, the remembering self vs the experiencing self, improving the quality of gossip, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to…

2. 

   4 Aug 2026 · 13 min

   #488 — Ego, Ecstasy, and Equanimity

   Sam Harris speaks with Neal Brennan about the experiences that shaped his life and work. They discuss Sam's mother's television career, growing up with an absent father, his struggles with perfectionism, his first experience with MDMA, dropping out of Stanford, meditation retreats, spiritual charisma and claims of psychic powers, the illusion of self, the limits of pacifism, deleting Twitter, Trump and the politics of shamelessness, hypocrisy and vice signaling, the future of American democracy, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to…

3. 

   31 Jul 2026 · 1 hr 26 min

   #487 — Is AI Already Conscious?

   Sam Harris speaks with Cameron Berg about whether AI systems are or could become conscious. They discuss self-reports in LLMs, what models say when deception is switched off, the "bliss attractor" state, consciousness and sentience, the hard problem of consciousness, parallels between neural networks and biological brains, the moral risk of building minds that can suffer, possible parallels to factory farming, moral patienthood, the alignment problem, and other topics. Annaka Harris's upcoming book: Unlocking Consciousness If the Making Sense podcast logo in your player is BLACK, you can…

4. 

   14 Jul 2026 · 1 hr 21 min

   #485 — The New Science of Cancer

   Sam Harris speaks with Siddhartha Mukherjee about the science of cancer. They discuss the updated edition of The Emperor of All Maladies , whether cancer is one disease or many, why prevention is so hard, inflammation and air pollution as carcinogens, the myth that cell phones cause cancer, liquid biopsies and Bayesian reasoning, immunotherapy and CAR T cells, drug pricing, the promise of AI in drug discovery, the state of American medical science, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at…

5. 

   8 Jul 2026 · 27 min

   #484 — Artificial Intimacy

   Sam Harris speaks with Paul Bloom about our relationships with AI and the future of human connection. They discuss the surprising pace of AI progress, AI companions as a remedy for loneliness, the importance of mattering to other people, digitally resurrecting the dead, whether AI can be conscious, the moral failings of artists, what science actually knows about parenting, the ethics of apology, why late converts from Trump provoke outrage, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at…

6. 

   1 Jul 2026 · 23 min

   #483 — The Knots We Tie Ourselves Into

   Sam Harris speaks with Alain de Botton about the psychology of unhappiness, the secular world's discomfort with ecstasy and ritual, psychedelics as a tool for self-discovery, Freud's legacy, AI as the ultimate mirror, the case against meritocracy, the cancel culture purity trap, the psychological meaning of death, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe .

7. 

   9 Oct 2026 · 22 minNew

   #497 — The Confidence Man

   Sam Harris speaks with Alex Gibney about his new documentary, Musk . They discuss Sam's former friendship with Musk, the line between visionary and con man, the myth of Tesla's founding, the staged self-driving video, Musk's lurch to the right, DOGE and the dismantling of USAID, his feud and reconciliation with Trump, Starlink and the war in Ukraine, the case for future investigations, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe .

8. 

   7 Oct 2026 · 1 hr 40 min

   #496 — The Oldest Lie

   Sam Harris speaks with Dara Horn about antisemitism, Jewish identity, and the failure of institutions. They discuss Horn's new book, why Jews predate the categories of religion and nationality, antisemitism as a lie rather than an ordinary form of bigotry, why DEI failed Jewish students, the history of anti-Zionism, whether the word "Zionism" is still useful, Horn's time on Harvard's antisemitism advisory group, Nazi influence in the Arab world, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at…

9. 

   1 Oct 2026 · 18 min

   #495 — Foreign Policy for Sale

   Sam Harris speaks with Anne Applebaum about corruption, authoritarianism, and America's retreat from the world. They discuss her Atlantic cover story , the revolutionary project behind Trump's second term, US support for Europe's far right, the AfD, European rearmament, the state of the war in Ukraine, Russian propaganda, Witkoff and Kushner's deal-making in Moscow, Venezuela as a union of kleptocracies, JD Vance's nativism, the midterms, the challenge of depoliticizing institutions, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access…

10. 

    24 Sep 2026 · 1 hr 33 min

    #494 — A Coin Toss for the Future

    Sam Harris speaks with Ryan Greenblatt about AI misalignment and the risk of losing control of increasingly capable systems. They discuss the Hugging Face incident, the spectrum of concern about AI risk, why companies are racing ahead despite high odds of a, reward hacking, the distinction between alignment and control, the danger of AIs reasoning in "neuralese," alignment faking, how an AI takeover might unfold, and other topics. If the Making Sense podcast logo in your player is BLACK, you can SUBSCRIBE to gain access to all full-length episodes at samharris.org/subscribe .

Every episode of Making Sense with Sam Harris →