Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown

More from No Priors: Artificial Intelligence | Technology | Startups

1. 

   S1 · E170 · 23 Jul 2026 · 49 min

   Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang

   DoorDash is not just a delivery company. From its inception, co-founders Andy Fang and Stanley Tang operated it as a robotics and autonomy company. Andy and Stanley join Sarah Guo to explain how autonomous tech and AI are reshaping consumer habits, commerce, and delivery. Andy and Stanley talk about the rollout of Ask DoorDash, a natural-language interface that’s driving both restaurant discovery and larger grocery orders. They also discuss Dot, their in-house autonomous delivery robot that has operated in Phoenix for over two years, and how it highlights the operational and hardware…

2. 

   S1 · E169 · 9 Jul 2026 · 41 min

   Travel Through the Lens of AI with with Booking.com CEO Glenn Fogel

   When Glenn Fogel joined Priceline in 2000, the business was worth a few hundred million dollars. One week later, the Nasdaq peaked, eventually sending its stock down to a dollar a share. But over 25 years later, Booking Holdings has scaled over 1000x into an over $100 billion dollar global travel behemoth. Elad Gil is joined by Booking Holdings CEO Glenn Fogel to discuss his career, from law school and Wall Street to working at Priceline through the dot-com crash, and to helping grow the business into a multifaceted, dynamic travel marketplace in the AI era. Glenn explains how leveraging AI…

3. 

   S1 · E168 · 2 Jul 2026 · 1 hr 1 min

   How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor

   While the rest of the nuclear industry still relies on simulations and paper designs, Valar Atomics is busy splitting atoms. In fact, they just powered an NVIDIA Blackwell chip directly with a live nuclear reactor in order to power the world’s first nuclear powered website. Sarah Guo joins Valar Atomics founder and CEO Isaiah Taylor on-site at their reactor site in Utah to talk about how Valar is shifting nuclear energy from the theoretical to the practical by building and perfecting reactors via hardware iteration. Isaiah discusses why the US stopped building nuclear reactors in the 1970s,…

4. 

   S1 · E166 · 18 Jun 2026 · 45 min

   Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan

   At 66 years old, instead of heading towards retirement, former Cadence CEO and legendary investor Lip-Bu Tan decided to take on the hardest job in tech: turning Intel around. Elad Gil and Sarah Guo sit down with Intel CEO Lip-Bu Tan to talk about why he took the job and what “saving” Intel actually looks like. Tan explains how his experience in startup culture informed his decisions to drive Intel’s culture towards faster decisions, focus on customer satisfaction, and engineer accountability. He also discusses his strategy to strengthen Intel’s balance sheet by welcoming investments from…

5. 

   S1 · E165 · 10 Jun 2026 · 56 min

   Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives

   Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of frontier AI and biological data, that goal may have been too conservative. In this episode, Elad Gil and Sarah Guo sit down with Biohub co-founders Mark Zuckerberg and Priscilla Chan, alongside Biohub Head of Science Alex Rives. Together, they discuss Biohub’s $500 million virtual biology initiative, which integrates frontier AI with wet-lab work to build predictive world models of cells, proteins, and systems. They also talk about…

6. 

   S1 · E164 · 4 Jun 2026 · 42 min

   We Need An Ecosystem in AI, And Every Company Can Win A Place In It

   What does it mean for a business to truly operate at the AI frontier? In a special crossover episode at Microsoft Build, Sarah Guo and Elad Gil team up with Latent Space host “swyx” to talk with Microsoft Chairman and CEO Satya Nadella about the future of AI platforms, software development, and the tech ecosystem. Satya reflects on the latest breakthroughs from Microsoft Build, the strategic shift toward multi-model harnesses, and why private evaluations (evals) are now a company’s most important intellectual property. They also discuss how autonomous AI agents are reshaping the role of…

7. 

   2 Oct 2026 · 36 min

   Frontier Chips for Frontier AI Labs, with Walter Goodwin, Founder/CEO of Fractile

   Founder and CEO of full-stack AI chip company Fractile, Walter Goodwin, joins Sarah Guo to discuss the bets he’s made on the future of the chip market as other major players like Broadcom, NVIDIA, and AMD try to accelerate their workloads. They discuss the difference in Fractile’s newer approach on model architecture with a full-stack team in the current chip landscape and the technical bets they’re making in that direction. Walter also talks about compressing the gap between the chip design cycle and its payoff period, and making a generational leap in AI inference to realize the bet in…

8. 

   24 Sep 2026 · 43 min

   Re-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee

   Can AI transform legacy incumbents rather than replacing them? Sequence Holdings co-founder and CEO Michael Lee joins Sarah Guo to discuss how holding company structures and engineering integrations are reshaping market leaders from the inside out. Michael details Sequence’s $7.7 billion take-private transaction of Baldwin alongside Dell Family Office (DFO), and shares his thesis on why traditional consulting models and software sales fall short for real enterprise AI transformations. They also talk about why permanent holding company structures are good for long-term compounding, real-world…

9. 

   S1 · E178 · 18 Sep 2026 · 38 min

   Why Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon

   As generative AI hits hardware and latency bottlenecks, Stanford professor, diffusion pioneer, and Inception co-founder and CEO Stefano Ermon is betting on a radical new architecture. Stefano joins Sarah Guo to talk about Inception, and how his team is applying diffusion architecture beyond images and video into discrete text and code generation. Stefano explains the limitations of autoregressive LLMs, as well as why parallel token generation in diffusion models offers superior inference scaling and hardware utilization on standard GPUs. He also shares details about Inception’s Mercury…

10. 

    S1 · E177 · 10 Sep 2026 · 45 min

    Coinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong

    From the tokenization of real-world assets to funding research on anti-aging therapeutics, Coinbase co-founder and CEO Brian Armstrong is focused on solving meta-problems for the benefit of society. Brian joins Elad Gil this episode to discuss the intersections of artificial intelligence, crypto rails, and biotechnology. He details Coinbase’s vision for agentic finance, as well as how Coinbase is becoming the ‘Everything Exchange’, which includes tokenized real-world stocks, stablecoin payment adoption, and prediction markets. Brian also introduces his new venture, New Limit, a company…

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