1008: The AI-Native Startup Playbook

More from Super Data Science: ML & AI Podcast with Jon Krohn

1. 

   21 Jul 2026 · 1 hr 10 min

   1011: The Math Still Matters: Deep Skills in the Age of AI, with Dr. Catherine Williams

   Dr. Catherine Williams, Chief Data Officer at the nonprofit Candid, was solving black-hole equations with pen and paper before she ever wrote a line of code. She earned a PhD in math researching general relativity and black holes, did postdocs at Stanford and Columbia and then became one of the very first data scientists, joining AppNexus back in 2012, around the same time “data scientist” became a job title at all. In this episode, she traces the field’s evolution from Bayesian models to BERT to today’s LLMs, and makes a compelling case that going deep on the underlying math matters more…

2. 

   17 Jul 2026 · 14 min

   1010: Fable 5 as Advisor: Anthropic's Two-Model Pattern for Smarter, Cheaper Agents

   In Episode #1010, Jon Krohn digs into “the advisor strategy”, a clever pattern that pairs a fast, cheap executor model with a frontier-class advisor it can consult mid-task, all inside a single API call. Every agent builder faces the same tension: frontier models plan best but cost too much to run on every turn, while small models fumble the decisions that matter. Anthropic’s advisor tool resolves it with roughly a one-line code change, and the benchmarks are startling: Sonnet with an Opus advisor scored higher than Sonnet alone while costing 11.9% less, and Haiku’s BrowseComp score more…

3. 

   14 Jul 2026 · 1 hr 7 min

   1009: How AI Is Quietly Saving Lives, with Steve Mock

   In Episode #1009, Steve Mock (investor at Blumberg Capital, five-time entrepreneur and creator of aisavedme.org), joins Jon Krohn to explore the quiet layer of everyday AI adoption that rarely gets documented. After his 84-year-old father asked a deceptively simple question, “How does one use AI?”, Steve built a place for people to share how AI is actually helping them. The stories that came in surprised him: they’re rarely about the technology and almost always about human outcomes, caregiving, communication, learning, confidence and connection. Additional materials:…

4. 

   7 Jul 2026 · 1 hr 36 min

   1007: How to Find Solid Career Ground in the AI Era, with 80,000 Hours Founder Ben Todd

   Benjamin Todd, co-founder and President of 80,000 Hours and author of the new Penguin Random House book 80,000 Hours: How to Have a Fulfilling Career That Does Good, joins Jon Krohn for a major update on career strategy in the AI era, his first appearance since before ChatGPT existed. Ben explains why “follow your passion” is backwards and why rare, valuable skills used to help others are what actually generate lasting fulfillment, the ABZ framework for planning under deep uncertainty, why the only durable move is to keep shifting onto whatever bottleneck AI can’t yet clear, and how a…

5. 

   3 Jul 2026 · 44 min

   1006: In Case You Missed It in June 2026

   In this month's episode of ICYMI, hear from Chip Huyen, Andrey Kurenkov, Frank Basso and Gilbert Eijkelenboom, discussing why moats are shifting toward physical systems and accumulated product intuition, how Astrocade built vibe coding before the term existed, what it's really like inside a deafeningly loud AI data center, why only 15% of people are technically self-aware and whether AGI requires anything like consciousness. Additional materials: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.superdatascience.com/1006⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Interested in sponsoring a SuperDataScience Podcast episode? Email…

6. 

   30 Jun 2026 · 1 hr 11 min

   1005: People Skills for Analytical Thinkers, with Bestselling Author Gilbert Eijkelenboom

   Gilbert Eijkelenboom, bestselling author of People Skills for Analytical Thinkers and founder of the training firm MindSpeaking joins Jon Krohn to make the case that communication is a core data skill, not an optional extra. Gilbert shares the “And, But, Therefore” framework for turning dense analysis into a story stakeholders act on, the research suggesting only around 15% of people are genuinely self-aware (and how journaling, meditation, and exercise help close that gap), how childhood experiences install behavioral “algorithms” we carry into the workplace and why behavior change precedes…

7. 

   9 Oct 2026 · 44 minNew

   1034: In Case You Missed It in September 2026

   In ICYMI Episode #1034, Jon Krohn moves from what sits underneath AI systems to what it takes to live with them every day. Hear from Aishwarya Srinivasan, Luis Serrano, Katie Malone, Ish Shah and Dilani Kahawala, discussing why the bottleneck in shipping software has moved from execution to judgment, how a physicist recast attention in transformers as words bending space, why years of managing people may be the best preparation for managing AI agents, how one weekend side project burned through billions of tokens and which three problems are hardest to solve when a product has no user…

8. 

   6 Oct 2026 · 1 hr 15 min

   1033: Workslop: The Hidden Cost of AI-Generated Work, with Prof. Jeff Hancock and Dr. Kate Niederhoffer

   In Episode #1033, Prof. Jeff Hancock (Professor of Communication at Stanford) and Dr. Kate Niederhoffer (Chief Scientist at BetterUp) join Jon Krohn to explain the hidden cost of AI-generated work. A year ago they coined "workslop" in a Harvard Business Review article that went viral and landed the term among Merriam-Webster’s words of the year: content that masquerades as real work but quietly shifts the burden onto whoever receives it. Their research finds that 40% of workers have been sent workslop and 53% admit to producing it, at a cost running to millions of dollars a year for a large…

9. 

   2 Oct 2026 · 28 min

   1032: Agents Need 10x More Data Than Humans, with Salesforce’s CDO Michael Andrew

   During their #sponsored discussion, Chief Data Officer at Salesforce Michael Andrew talks to Jon Krohn about what changes for a data team when its customers are AI agents as well as people. Listen to the episode to hear Michael Andrew talk about why agents need ten times more trusted data than humans, how Salesforce untrapped its own customer data with Data 360 and what practitioners should be learning to stay effective in the agentic era! Additional materials: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.superdatascience.com/1032⁠⁠ Interested in sponsoring a SuperDataScience Podcast episode? Email…

10. 

    29 Sep 2026 · 1 hr 15 min

    1031: Tokenomics: Why Your Agentic AI Bill Is Exploding (and How to Fix It), with Tyler Cox and Ish Shah

    In Episode #1031, Ish Shah and Tyler Cox (Distinguished Engineers in the Office of the CTO for Dell Technologies' client group) join Jon Krohn to work out why agentic AI bills are exploding and what can be done about it. Over one weekend Ish burned roughly two billion tokens on a side project, and that is the ordinary shape of agentic work now: agents spawn sub-agents, the pie of work grows, and cheaper tokens only invite more ambitious projects. Tyler runs a small Dell lab that pushes hundreds of millions of tokens a day through local hardware instead. In this episode, they define what…

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