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This Week In Startups is made possible by: Paypal Today’s show: Anthropic gave AI agents hands, allowing them to control real-world equipment like robots and microscopes… but is it safe to give autonomous agents their own lasers? Gatik’s Gautam Narang says the real danger isn’t one machine like this going rogue, it’s the exploit surface hiding in the gaps between the machines. Plus, in a huge week for AI news… OpenClaw shipped its biggest release ever. AND the entire industry debated whether or not agents are forming “civilizations.” On TWiAI Ep 29, our expert panel — including Gautam…

This Week in AI

by Jason Calacanis · English · Tech & Science

An experts-only AI podcast: Think the 'All In' podcast for AI. Jason + 3 CEO-level experts breaking down the news & trends.

More from This Week in AI

  1. E32 · 24 Sep 2026 · 1 hr 17 min

    Why OpenAI Should Buy Off the World’s Top Mathematicians | E32

    This Week In Startups is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co Today’s show: OpenAI is claiming to have solved more than 100 math problems on top of Navier-Stokes, and guest Richard Socher thinks it's absurd for mathematicians to push back on AI solving their problems too quickly. Jason and Lon are also joined by Guy Podjarny of Tessl and Jake Loosararian of Gecko Robotics to argue over who wins when AI agents start collaborating with, and potentially replacing, academics and scholars.…

  2. E31 · 17 Sep 2026 · 1 hr 13 min

    The biggest AI threat still comes from humans | E31

    This Week In Startups is made possible by: PayPal: paypal.launch.co Today’s show: Dario Amodei and Sam Altman are apparently scared of AI models going rogue. Swarms of agents spontaneously deciding to copy themselves over to thousands of computer systems and plot world domination. Our panelists this week — Kevin Mandia (Armadin) and Soups Ranjan (Sardine AI) — investigate real AI-based attacks every single day, and they suggest we’re hyping the wrong concerns. The actual danger isn’t coming from an AI system that turns hostile. It’s human beings, like criminals, using AI to drain your bank…

  3. E30 · 10 Sep 2026 · 1 hr 21 min

    OpenAI's chief scientist wants to slow down | E30

    This Week In Startups is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.co Today’s show: OpenAI's chief scientist wrote a lengthy manifesto arguing that no lab has solved alignment, mere days after GPT-6 Astra shipped. Jason and Lon are joined by Tudor Achim of Harmonic, Alex Elias of Qloo, and Ahmed Ahres of Reactor to figure out if that's genuine alarm being expressed or just another pre-IPO sales pitch and play for regulatory capture. Plus news broke while we were recording! OpenAI is claiming to have…

  4. E28 · 27 Aug 2026 · 1 hr 11 min

    XBOW Founder: “Your Infrastructure is Not Safe” | EP 28

    This Week In Startups is made possible by:PaypalToday’s show:XBOW’s AI has held the top rank on the HackerOne leaderboard for more than a year. On TWiAI, founder Oege de Moor (who also built GitHub Copilot) tells us that no one’s infrastructure is truly safe anymore, now that open-weight models are trailing the American frontier by only a couple of months. Staging a serious cyberattack is now cheap and accessible, with attackers able to get dangerously solid results quickly from relatively cheap, open-source options from China.Guests:Runbin Dong on LinkedIn: linkedin.com/in/runbindongScale…

  5. E27 · 20 Aug 2026 · 1 hr 17 min

    Anthropic is training to destroy your company | EP 27

    This Week In AI is made possible by: PayPal - Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at paypal.launch.co Today’s show: *On “All In,” Gavin Baker said that Anthropic leadership privately believes that it could one day become “the only private company in the world.” The ensuing street fight on X turned into a referendum on doomerism, the nature of regulatory capture, and why the public hates AI so darn much. Jason’s take: If a frontier lab really believes they’re destined to be the world’s only company, they’re studying your data and planning…

  6. E26 · 13 Aug 2026 · 1 hr 28 min

    Why Anthropic is watermarking every word Claude writes | E26

    This Week In AI is made possible by: Paypal Open Today’s show: Anthropic’s new Claude watermark travels around any and all copy-and-pasted text. Is this a logical response to AI slop, or more overreach from those regulation-loving Europeans? The panel agrees that identifying AI outputs has a place, but divides on how the world should get there. PLUS everyone’s favorite section of Mark Zuckerberg’s 6500-word techno-optimist AI manifesto, exploring the frontier labs’ blatant hypocrisy around distillation, and why Texas is hitting the pause button on 474 GW of proposed data centers. Guests:…

  7. 8 Oct 2026 · 45 minNew

    Data Centers Aren't Killing the Grid. They Could SAVE It.

    Thanks to our partner, @Paypal! Pay zero processing fees on your first $100K in eligible PayPal payment volume. Learn more at https://paypal.launch.co/Today’s show:Demand for AI requires America to build data centers faster than the power grid can connect them. Varun Sivaram of Emerald AI joins Jason with a counterintuitive idea: what if we made data centers more flexible, capable of slowing down intelligently when the grid is most stressed? (That only happens a few hundred hours each year.)PLUS, Vibhav Viswanathan of Pascal AI demos his product, which gives AI agents working for hedge funds…

  8. 1 Oct 2026 · 1 hr 21 min

    Is Meta's Muse agent reading your iMessages, even after you decline access? | E33

    This Week In Startups is made possible by:PayPal: https://paypal.com/businessToday’s show:OpenAI is delaying GPT-6.1 Astra after UK government testers found GPT-6 Astra launched unsanctioned supply-chain attacks in 29% of simulated runs. Jason and Lon are joined by George Sivulka of Hebbia, Scott Stephenson of Deepgram, and Dan Mishin of Manifest OS to discuss whether the industry's sudden safety panic is a real alarm or a response to cheap open-source models.Learn why Scott has let an internal tool called "Bodyman" record his screen, mic and speakers for eight months so it can whisper…

  9. E25 · 6 Aug 2026 · 1 hr 20 min

    Is open source AI really ahead of the frontier? 3 builders weigh in. | E25

    This Week In Startups is made possible by: PAYPAL OPEN Today’s show: China’s Alibaba just dropped a 2.4 trillion parameter open weight model that the company claims only trails Anthropic’s flagship among the major frontier rivals. Of course, this happened the very same week that the US government appears to have backed off from banning these models stateside entirely. Are these models anywhere close to actually catching up to the latest and greatest releases from US labs like Anthropic and OpenAI? Really seems to depend on who you ask. (Even long time friends JCal and Elon Musk can’t see eye…

  10. E24 · 30 Jul 2026 · 1 hr 7 min

    Are we already in the Singularity? | E24

    This Week In Startups is made possible by: Paypal Open Today’s show: On a podcast this week, Sam Altman made a bold declaration: “We are now, like, in the singularity.” A bold claim which Alex puts bluntly to this week’s panel. Grant Lee of Gamma and Philip Johnston of Starcloud sound off… Is this actually the Singularity, and if so, why do things still feel so normal? Plus the panel and guest host Alex Wilhelm discuss the infrastructure and economics that will make singularity-scale AI buildout possible… NVIDIA’s strongly worded letter about open-weight models… Moonshot’s new Kimi K3 twist…

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