Podcast · Tech & Science

Big Brains

by University of Chicago Podcast Network · English · Tech & Science

Big Brains explores the groundbreaking research and discoveries that are changing our world. In each episode, we talk to leading experts and unpack their work in straightforward terms. Interesting conversations that cover a gamut of topics from how music affects our brains to what happens after we d

New episodes: Every two weeks
Typical length: 36 min
Latest: 9 Oct 2026
Language: English

Latest episode

9 Oct 2026 · 36 min

Neutrino Hunters: Searching for Ghostly Particles in Antarctic Ice, with Abigail Vieregg

Deep beneath the ice of Antarctica and high above its frozen expanse, University of Chicago astrophysicist Abby Vieregg is hunting for neutrinos—some of the most elusive particles in the universe. Often called "ghost particles," these tiny messengers travel across billions of light-years, passing right through ordinary matter unnoticed. She is among the many scientists hunting for high-energy neutrinos—an area of research that was awarded the 2026 Nobel Prize in Physics. In this episode, Vieregg discusses how her team designs and launches cutting-edge radio detectors—from high-altitude NASA…

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Earlier episodes 29 most recent

E202 · 17 Sep 2026 · 37 min
Recreating A Sense of Touch, Using Our Minds, with Nicholas Hatsopoulos
What if your thoughts could allow you to feel the texture of an object, type a message or move a robotic arm? How does the brain translate thought into physical movement, and can technology bridge the gap for paralyzed patients, whose pathways are broken? University of Chicago neuroscientist Nicholas Hatsopoulos is transforming that fundamental neuroscience into life-changing medical technology. By implanting microelectrode arrays directly into the brain, his team decodes the neural patterns that fire when a person intends to move. This brain-machine interface technology is allowing patients…
E201 · 20 Aug 2026 · 37 min
Why The Key to Treating Cancer May Be In Your Gut, with Thomas Gajewski
For decades, traditional cancer treatments like chemotherapy and radiation have targeted tumors directly—often with severe side effects and mixed results. But what if the key to treating cancer was already inside our bodies? Prof. Thomas Gajewski, a renowned oncologist at the University of Chicago, is leading a revolution by using the body’s gut microbiome to fight cancer. His pioneering work in cancer immunotherapy focuses on why some patients with melanoma responded dramatically to immune-based therapies while others do not. In this episode, Gajewski discusses how training T-cells to…
E200 · 6 Aug 2026 · 34 min
The Little-Known Secrets To A Good Life, with Shigehiro Oishi
What makes a good life? For decades, psychologists have debated whether true fulfillment comes from happiness—a life of comfort and joy—or meaning—a life of purpose and impact. But what if there's a third way? University of Chicago psychology professor Shigehiro Oishi has spent his career studying happiness, meaning, and what truly brings people deep satisfaction. His new research suggests that some of the most fulfilled people don’t prioritize either—they live psychologically rich lives, full of novelty, challenges, and transformative experiences. In this episode, Oishi explains why…
E199 · 23 Jul 2026 · 35 min
How to Use Nature to Restore Your Focus, with Marc Berman
What if the secret to restoring your focus, improving your mental health, and even reducing crime rates wasn’t found in an app or a pill, but in a tree? In this episode, we speak with University of Chicago psychologist Marc Berman, whose research on “soft fascination” and nature’s cognitive effects is reshaping how we think about everything from urban planning to depression treatment. From groundbreaking hospital studies to surprising results with plastic plants, Berman’s work uncovers the deep—and often invisible—power that natural environments hold over our minds and bodies. Whether you're…
E198 · 9 Jul 2026 · 33 min
How to Raise Kids in the Age of AI, with Dana Suskind
As AI rapidly changes how we work, learn, and communicate, it also raises an urgent question: What does it mean to grow up in a world dominated by smart technology? From smart-baby monitors to stuffed animals embedded with LLMs, kids and parents are increasingly bombarded with AI everywhere they turn. According to Prof. Dana Suskind, a renowned surgeon and pediatrician at the University of Chicago, AI might be able to mimic language, logic, and creativity, but it cannot replace the deeply relational, responsive human interactions that are crucial to a child’s development. In her latest book,…
E197 · 25 Jun 2026 · 37 min
What Our Trash Problem Says About Our Culture, with Sarah Newman
Every day, we throw things away, only to be forgotten forever. But society didn’t always work in the same way. In this episode, we speak with University of Chicago scholar and anthropologist Sarah Newman to discuss her book, Unmaking Waste: New Histories of Old Things. An archaeologist by training, Newman discusses the history of trash across time—from the ancient Mayan civilization through today’s disposable culture. She argues that other societies valued objects much more deeply, reusing and recycling items in innovative ways. But will we ever return to this kind of zero-waste mentality?…
E196 · 11 Jun 2026 · 37 min
How Websites Trick You Using ‘Dark Patterns’ with Marshini Chetty
Why does it seem so difficult to cancel an online subscription, delete an account, or opt out of data tracking? You might think it’s just bad luck or a confusing online interface, but more often than not, it’s by design. In this episode of Big Brains, we speak with Marshini Chetty, Professor in the University of Chicago’s Department of Computer Science. As a leading expert in human-computer interaction, Chetty reveals the science behind "dark patterns” online—the subtle, manipulative design choices woven into the apps and websites we use every day. We explore how these deceptive interfaces…
E195 · 28 May 2026 · 40 min
Quantum Technology, Explained: A Big Brains Live Event
Quantum technology is at a pivotal moment. No longer the faraway dream of scientists, the field is rapidly developing across the world, fueled by major investments from governments, industry, and universities racing to lead its promising future. But what exactly is quantum technology? And how will it affect our lives today—and in the coming decades? A recent event at the University of Chicago, hosted by Big Brains in partnership with 1440, sought to demystify quantum, separate the hype from reality and explore how it could transform our daily lives. Three renowned scientists—Prof. David…
E194 · 14 May 2026 · 39 min
Our Untapped Superpower: Connecting With Others, with Nicholas Epley
As humans, we have a biological need for connecting with others, but in today's modern world, we tend to avoid it. This paradox is something that Prof. Nicholas Epley of the University of Chicago Booth School of Business has been fixated on in his research. In his new book, A Little More Social: How Small Choices Create Unexpected Happiness, Health, and Connection, Epley shows why we consistently underestimate the positive impact of reaching out to others. From experiments tracking commuters on the train to deep conversations with hedge fund executives, Epley reveals that our beliefs about…
E193 · 30 Apr 2026 · 37 min
Why the Fed Matters Now More Than Ever, with Douglas Diamond
From setting interest rates to keeping inflation in check, the Federal Reserve sits at the center of some of the most important economic decisions shaping our daily lives. As the Fed prepares for new leadership, following the tenure of Jerome Powell, many are wondering: What’s next for the Fed, especially when it comes to their financial decisions and their independence? We spoke with Prof. Douglas Diamond, the Nobel Prize-winning economist of the University of Chicago, in order to explain the Fed’s crucial role in our financial system—and why it matters so much for our future. Renowned as…
E192 · 16 Apr 2026 · 37 min
Anxious? Avoidant? How to Build More Secure Relationships
What if the way you relate to others isn’t fixed—but fundamentally changeable? In this episode, we speak with psychiatrist and neuroscientist Amir Levine, who is an Associate Professor of Clinical Psychiatry at Columbia University Medical Center. He's the author of the best-selling book Attached, which examined how people’s attachment styles—from secure to anxious to avoidant. In his new book, Secure: The Revolutionary Guide to Creating a Secure Life, Levine argues that attachment styles aren’t lifelong labels but actually patterns the brain can relearn. He explores the emerging science of…
E191 · 2 Apr 2026 · 35 min
Could AI Models Forecast Extreme Weather Events? with Pedram Hassanzadeh
What if we could predict the world’s most dangerous weather events—not days, but weeks in advance? Extreme events like heat waves, hurricanes, and floods cause massive loss of life and billions in damage, but they’re also some of the hardest events for traditional weather forecasting to predict. In this episode, Assoc. Prof. Pedram Hassanzadeh of the University of Chicago explains why forecasting extreme weather has long pushed science to its limits—and how a new wave of AI models could transform the field at a time when climate change is making these events more common. By learning directly…
E190 · 19 Mar 2026 · 40 min
Are Judges Too Powerful? The Rise of Universal Injunctions, with Samuel Bray
In recent years, a judge in one state had gained the power to halt policies across the entire United States. Known as nationwide or universal injunctions, these actions have become one of the sweeping tools in the federal court—affecting cases ranging from student loan forgiveness to environmental policies to birthright citizenship. How did universal injunctions become such a central feature of modern constitutional battles? And should one judge really be able to block a policy for the entire country? In this episode, UChicago legal scholar Samuel Bray explains the history and legal debate…
E189 · 6 Mar 2026 · 37 min
Could Data Centers Break Our Power Grid? with Andrew Chien
Artificial intelligence may live in “the cloud,” but its footprint is firmly on the ground. As AI systems grow more powerful, the data centers that train and run them are consuming massive amounts of land, water and electricity—as well as reshaping regional power grids. What does this surge in demand mean for the environment, energy infrastructure, and the future of innovation? In this episode, we speak with UChicago computer scientist Andrew Chien, an expert in large-scale computing and cloud computing, about why these data centers require so much power, why they’re stirring such…
E188 · 19 Feb 2026 · 26 min
Remarkable New Treatments for Spinal Cord Injuries, with Mohamad Bydon
When a two-year-old boy suffered a catastrophic injury that severed the connection between his skull and spine, doctors across Europe told his family there was no hope. His spinal cord was completely severed, and the injury was not considered survivable. But University of Chicago neurosurgeon Mohamad Bydon saw a possibility. In this episode of Big Brains, Dr. Bydon walks us through the extraordinary, multi-stage surgery at UChicago that not only saved the boy’s life but helped him regain the ability to breathe, talk and move his fingers and toes. He examines the future of surgery for spinal…
E187 · 5 Feb 2026 · 36 min
Can You Improve Your Working Memory and Attention? with Edward Awh
In today’s world, our brains are overloaded with information, making it hard to focus and remember. But what are the true limits of the human mind—and why do they exist? And why are some people seem so much better than remembering things than others? In this episode, we talk with with Edward Awh, a cognitive neuroscientist and professor of psychology at the University of Chicago. Whose lab studies how the brain controls focus, memory and attention. His research explores the connection between attention and working memory, why our conscious awareness is far more limited than it feels, and…
E186 · 22 Jan 2026 · 32 min
Why Knowing Your True Self Is So Difficult, with Eric Oliver
The process of understanding who we are is a lifelong journey for many of us. For two decades, that question has been one that University of Chicago scholar Eric Oliver has asked his students in class—and inspired him to write a new book called "How to Know Your Self: The Art & Science of Discovering Who You Really Are." A renowned political scientist, Oliver draws upon science, philosophy, psychology and his personal experiences to better examine the mysteries of the human experience—and explore what it truly means to be “you.”
E185 · 8 Jan 2026 · 36 min
The Breakthrough Quantum Sensor That Sees Inside Your Cells, with Peter Maurer
What if we could precisely measure a cell at its most fundamental level? In this episode, we talk with the University of Chicago scientist Peter Maurer about how he and his colleagues made the breakthrough discovery of turning a protein found in living cells into the first biological quantum bit, also known as a qubit. Maurer explains how quantum systems—once thought to be too fragile for real-world use—are becoming some of the most powerful sensors ever built, and what they could teach us about the brain, the body and more.
E184 · 29 Dec 2025 · 32 min
How to Manifest Your Destiny with the Late James Doty
We've all heard the phrase "Manifest Your Destiny" when it comes to wanting a new promotion, figuring out a new career path or just trying to achieve that long-term goal. It turns out that the act of manifestation is not merely pseudoscience—it actually has a body of research in neuroscience to back it up. James Doty was a clinical professor of neurosurgery at Stanford University, and founder and director of the Center for Compassion and Altruism Research and Education. He wrote several books, including "Mind Magic: The Neuroscience of Manifestation and How It Changes Everything".
E183 · 11 Dec 2025 · 36 min
What Makes Music Go Viral—From AI to Taylor Swift
The internet and social media have transformed the way in which we hear and understand music today—and online communities and platforms from YouTube to TikTok have changed how music circulates and ultimately goes viral. Why do some pop stars have more success creating hit songs and building online following than others? In this episode, we speak with Paula Clare Harper, a musicologist and assistant professor at the University of Chicago. Harper co-edited the book Taylor Swift: The Star, The Songs, The Fans, which explores the online musical cultures that produced and propelled the image of…
E182 · 24 Nov 2025 · 38 min
How Wearable Tech Will Heighten Our Senses and Abilities, with Pedro Lopes
Can you imagine a world in which a wearable device, like a smartwatch, could move your fingers to strum the guitar or play the drums? That kind of technology is part of the innovative research coming out of the Human-Computer Integration Lab at the University of Chicago, led by renowned computer scientist Pedro Lopes. His lab is developing a new generation of gadgets that use haptics (or tactile sensations like the buzz of your smartphone) to move your body, replicate your sense of smell and even make you feel things. In this episode, Lopes explores the potential of wearable devices to…
E181 · 13 Nov 2025 · 32 min
Why Are More Women Saying No To Having Kids? With Peggy O'Donnell Heffington
More and more women in the United States are saying no to motherhood. In 2023, the U.S. fertility rate reached the lowest number on record. But the idea of non-motherhood is actually not a new phenomenon, nor did it come out of the modern feminist movement. For centuries, women have made choices about limiting births and whether or not to become mothers at all. This history is documented in a new book, "Without Children: The Long History of Not Being a Mother," by University of Chicago Assistant Instructional Professor Peggy O'Donnell Heffington. Heffington writes about the historic trends…
E180 · 30 Oct 2025 · 35 min
How Full-Body MRIs Could Predict Your Long-Term Health, with Daniel Sodickson
What does it mean to see beneath the surface — of the human body, the brain, or even the universe itself? In his new book, The Future of Seeing: How Imaging Is Changing Our World, Prof. Daniel Sodickson of NYU explores the future of imaging: How technology is transforming not just medicine, but our very ways of perceiving the world. With the rise of AI-driven “digital vision,” Sodickson, a pioneer of MRI innovation, argues that imaging is no longer just a diagnostic tool — it’s becoming a new language of discovery. In this conversation, Sodickson explores the promises and pitfalls of this…
E179 · 16 Oct 2025 · 36 min
Is There Such A Thing As A Psychopath?
Few ideas have gripped the public imagination quite like the idea of the “psychopath.” From Hollywood thrillers to true-crime podcasts, popular culture has led us to believe that psychopaths are dangerous and biologically distinct from the rest of us. But what if almost everything we think we know about them is wrong? In this episode, we talk with Rasmus Rosenberg Larsen, an Assistant Professor of Forensic Epistemology at the University of Toronto and author of "Psychopathy Unmasked," whose research is challenging the very foundation of psychopathy as a diagnosis. Larsen explains how the…
E178 · 2 Oct 2025 · 36 min
Why We Haven’t Solved Brain Disorders—And How To Fix It, with Nicole Rust
For decades, neuroscience has promised breakthroughs in treating conditions like depression, schizophrenia, and Alzheimer’s. Yet despite powerful technologies and billions invested, progress has been frustratingly slow. Why? On this episode of Big Brains, we talk with Nicole Rust, neuroscientist at the University of Pennsylvania and author of Elusive Cures. Rust argues that the traditional “domino” view of the brain—where one broken piece can simply be fixed—has held us back. Instead, she says we need to embrace the brain’s true nature: a complex, dynamic system more like the weather than a…
E177 · 19 Sep 2025 · 31 min
Life On Mars: Is It Possible For Humans? with Edwin Kite
Billions of years ago, Mars may have looked less like the barren red desert we know today and more like Earth—with a blue sky, flowing rivers, and even seas. What happened to turn a once-habitable world into the frozen, lifeless planet we see now? On this episode of Big Brains, University of Chicago geophysical scientist Edwin Kite takes us on a journey through Mars’ hidden past. From evidence of a lost carbon cycle to theories about ancient climate swings, Kite’s research is rewriting the story of the Red Planet. But it’s not just about the past—his work is also at the forefront of a…
E176 · 4 Sep 2025 · 32 min
How To Use Nature To Restore Your Focus, with Marc Berman
We’re living in an attention economy—and most of us are broke. But what if the secret to restoring your focus, improving your mental health, and even reducing crime rates wasn’t found in an app or a pill, but in a tree? In this episode, we speak with University of Chicago psychologist Marc Berman, whose research on “soft fascination” and nature’s cognitive effects is reshaping how we think about everything from urban planning to depression treatment. From groundbreaking hospital studies to surprising results with plastic plants, Berman’s work uncovers the deep—and often invisible—power that…
E175 · 21 Aug 2025 · 25 min
Could Plants Unlock Quantum Medicine’s Potential? with Greg Engel
We’ve long marveled at how efficiently plants convert sunlight into energy—but no one guessed they were using quantum mechanics to do it. In this episode, we speak with Greg Engel, a pioneering biophysicist at the UChicago Pritzker School of Molecular Engineering and the Department of Chemistry who helped launch the field of quantum biology. Engel explains how plants and bacteria evolved to exploit quantum effects for photosynthesis—and how understanding these systems could spark a revolution in quantum sensing, medicine, and neuroscience. Engel’s team has already built quantum sensors…
E174 · 7 Aug 2025 · 28 min
How Microplastics Are Invading Our Bodies, with Matthew Campen
You’ve heard of plastic polluting oceans. But what if it’s polluting you—your brain, your reproductive system, even your unborn children? In this eye-opening episode, we speak with Prof. Matthew Campen, a scientist at the University of New Mexico, whose latest studies have uncovered evidence of microplastics in placentas, reproductive organs and brains of humans—particularly in the frontal cortex, where decision-making and personality live. We explore how these plastic particles are entering our bodies (hint: it’s not just your water bottle), what they might be doing to us, and why…

About Big Brains

Big Brains is a English tech & science podcast from University of Chicago Podcast Network. Melo plays each episode straight from the publisher's own feed — no ads added, no account needed — and remembers where you stopped, in this browser only.

Publisher: University of Chicago Podcast Network
Language: English
Category: Tech & Science
New episodes: Every two weeks
Typical length: 36 min
Latest episode: 9 Oct 2026
Feed: RSS — paste into any podcast app
Apple Podcasts: podcasts.apple.com/podcast/id1368737097

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