Podcast · Health

CLDF Podcast

by Chronic Liver Disease Foundation · English · Health

The official podcast channel for the Chronic Liver Disease Foundation.

New episodes: Weekly
Typical length: 10 min
Latest: 24 Sep 2026
Language: English

Latest episode

24 Sep 2026 · 45 min

Viral Hepatitis Guideline Update

Explore the evolving management of chronic hepatitis B (HBV) with Drs. Ira Jacobson, Paul Martin, and Robert Gish in the first installment of the What’s New in Hepatitis B series. This case-based discussion reviews hepatitis B treatment guidelines, comparing published recommendations with the panel’s perspectives on antiviral treatment eligibility, HBV DNA and ALT thresholds, and managing patients with high viral loads and normal liver enzymes or indeterminate-phase disease. The experts also address shared decision-making and the importance of considering stigma, quality of life, and patient…

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Earlier episodes 29 most recent

22 Sep 2026 · 13 min
Linerixibat Medication Review
Christina Hanson, FNP, and Dr. Marcelo Kugelmas of South Denver Gastroenterology review linerixibat, an ileal bile acid transporter (IBAT) inhibitor, and its role in managing cholestatic pruritus in primary biliary cholangitis (PBC). This medication review podcast explores how blocking bile acid reabsorption in the ileum targets a pathway involved in persistent itching. The discussion covers the phase 2 GLIMMER study and phase 3 GLISTEN trial, including findings on itch reduction, sleep interference, and treatment response in patients with moderate to severe pruritus. The speakers also…
15 Sep 2026 · 15 min
Managing Fatigue and Pruritus in Your Patients With PBC
How can clinicians better recognize and manage itching and fatigue in primary biliary cholangitis (PBC)? In this podcast, hepatology clinicians from RUSH University Medical Center discuss the impact of PBC-related pruritus and fatigue on sleep, daily activities, and quality of life. The conversation explores proactive symptom screening, assessing itch severity, and individualizing treatment with options such as cholestyramine, PPAR therapies, rifampin, and sertraline. The speakers discuss how their treatment approaches have evolved and why ongoing communication helps identify when symptom…
3 Jun 2026 · 13 min
Optimizing Clinical Pathways to Achieve Functional Cure in CHB
In this educational podcast, Paul Kwo, MD discusses how the goals of hepatitis B treatment are changing and what the future may look like for people living with chronic hepatitis B. While current medications do an excellent job of controlling the virus, most patients still need to stay on treatment long term. Dr. Kwo explains the growing focus on achieving a “functional cure,” which means losing the hepatitis B surface antigen—a key milestone that may allow some patients to eventually stop treatment and further reduce their risk of serious liver complications. Throughout the presentation,…
12 May 2026 · 5 min
Insights From 2025 EASL & AASLD Chronic Hepatitis B Guidelines
Dr. Anthony Martinez, Medical Director of Hepatology at the University at Buffalo and Erie County Medical Center, discusses the evolving landscape of chronic hepatitis B management and the shift from viral suppression to precision immune control. In this expert overview, he highlights the latest 2025 AASLD and EASL guideline updates and explains how quantitative hepatitis B surface antigen (qHBsAg) testing is changing treatment decisions, particularly for hepatitis B e antigen-negative patients. This discussion explores when clinicians may consider stopping nucleos(t)ide analog therapy, the…
6 May 2026 · 21 min
Navigating Non-Adherence and Compliance in Wilson's Disease
In this expert discussion presented in collaboration with the Chronic Liver Disease Foundation, Amanda Cheung, MD, transplant hepatologist at Northwestern Medicine, and Peter Hedera, MD, neurologist and medical geneticist at University of Louisville, explore the complex challenges of medication adherence and long-term compliance in patients with Wilson disease. This educational conversation reviews the lifelong management of Wilson disease, highlighting how both neurologic and hepatic manifestations can significantly impact quality of life, daily functioning, and long-term outcomes. The…
22 Apr 2026 · 6 min
The Multidisciplinary Team: Your Guide to Cirrhosis and Portal Hypertension Care
In this informative CLDF podcast, Sammy Saab provides a clear, big-picture overview of cirrhosis and portal hypertension, breaking down how clinicians approach this complex condition in today’s evolving healthcare landscape. Rather than focusing on technical details, this discussion highlights the key ways cirrhosis impacts the body and why early recognition, ongoing monitoring, and coordinated care are so important for improving patient outcomes. The episode emphasizes how cirrhosis is best understood in stages—from earlier phases where lifestyle changes and preventive care can make a…
22 Apr 2026 · 30 min
Wilson Disease: Therapeutic Landscape & Future Directions
In this insightful CLDF podcast recorded at the 6th Annual Liver Connect Conference, John Vierling, MD, shares a forward-looking overview of Wilson’s disease and the major shifts shaping its future diagnosis and management. This episode explores why Wilson’s disease remains difficult to recognize, often going undiagnosed for years due to its wide range of symptoms and its ability to mimic more common conditions. The conversation highlights the real-world challenges faced by patients, families, and clinicians, including inconsistencies in care and the impact on quality of life. Looking ahead,…
22 Apr 2026 · 11 min
What You May Be Missing: Screening For Wilson Disease in Routine Clinical Practice
In this engaging CLDF podcast episode, Fred Gordon, MD, and Valentina Medici, MD, explore the fundamentals of Wilson’s disease and why it remains one of the most challenging liver conditions to recognize in clinical practice. The conversation focuses on the importance of awareness, highlighting how this rare disease can present in many different ways and often goes overlooked or misdiagnosed. Listeners will gain a high-level understanding of when to consider Wilson’s disease, why early detection is so important, and how clinicians approach the diagnostic journey. The discussion also touches…
22 Apr 2026 · 21 min
Complications of Cirrhosis: The Basics
In this high-level hepatology update from the 6th Annual Liver Connect Conference, Sujit Janardhan, MD, PhD, provides an overview of how the understanding and management of cirrhosis and portal hypertension are evolving in 2026. The discussion focuses on the big-picture shifts in the field, including earlier identification of patients at risk, updated definitions of disease progression, and how these changes are influencing overall treatment approaches. Rather than focusing on individual therapies in depth, this session highlights how clinicians are thinking differently about preventing…
22 Apr 2026 · 10 min
TIPS Procedure: Identifying Candidates and Minimizing Risk
This educational podcast from the 6th Liver Connect meeting provides a comprehensive overview of the TIPS (transjugular intrahepatic portosystemic shunt) procedure, focusing on patient selection, risk stratification, and evolving techniques to improve outcomes in patients with advanced liver disease. The discussion highlights key indications for TIPS, including recurrent or high-risk variceal bleeding, refractory or recurrent ascites, and select cases of portal vein thrombosis or hepatic venous outflow obstruction such as Budd-Chiari syndrome. Learn how early TIPS intervention can reduce…
15 Apr 2026 · 10 min
Timing Is Everything: When is TIPS Appropriate?
In this educational overview, Ethan Weinberg, MD, breaks down the fundamentals of portal hypertension and when to consider TIPS (transjugular intrahepatic portosystemic shunt) in clinical practice. The discussion highlights how clinically significant portal hypertension (CSPH) is diagnosed using both invasive and non-invasive methods, and reviews first-line management with non-selective beta blockers like carvedilol. The video focuses on key indications for TIPS, including variceal bleeding and ascites, emphasizing growing evidence that earlier intervention can improve outcomes, reduce…
2 Apr 2026 · 15 min
How to Monitor Patients With Compensated Cirrhosis
This educational video featuring Dr. Rustgi reviews key updates in hepatology, including HCC surveillance in compensated cirrhosis and the emerging role of liquid biopsies for earlier, more accurate cancer detection. It highlights the limitations of traditional tools like ultrasound and AFP, while introducing advances such as circulating tumor DNA and other minimally invasive biomarkers. The discussion also covers subclinical portal hypertension and the use of HVPG and non-invasive tools for early risk stratification, along with practical applications across patient populations, including…
2 Apr 2026 · 7 min
Management of Portal Hypertension
This educational podcast with Dr. Sobia Laique from the 6th Annual Liver Connect meeting reviews key updates in the management of portal hypertension, focusing on improving outcomes beyond first variceal bleed prevention. The discussion highlights the advantages of carvedilol over propranolol, including its dual mechanism and greater reduction in portal pressure, with evidence supporting its role as first-line therapy in many patients. The episode also covers the Baveno VII criteria, demonstrating how non-invasive tools like liver stiffness and platelet count can safely reduce the need for…
2 Apr 2026 · 3 min
Navigating Treatment Options in 2026
Explore the latest treatment strategies and emerging trends in metabolic dysfunction–associated steatohepatitis (MASH) with expert insights from Dr. Nadege Gunn. This video covers current FDA-approved therapies for patients with moderate to advanced fibrosis, including Resmetirom (Rezdiffra) and Semaglutide, and explains how lifestyle interventions remain the foundation of care. Learn how to personalize treatment decisions based on patient comorbidities such as obesity and type 2 diabetes, when to initiate GLP-1 therapy versus resmetirom, and how these therapies can be used together in…
2 Apr 2026 · 7 min
Best Practices in Ongoing Monitoring of MASH Patients
Learn best practices for identifying, risk stratifying, and managing patients with metabolic dysfunction–associated steatohepatitis (MASH) in this expert-led webcast featuring insights from Dr. Sammy Saab. As MASH continues to rise as a leading cause of cirrhosis, liver cancer, and liver transplantation, this session explores the evolving clinical approach to evaluation and treatment in the context of the broader spectrum of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Discover why traditional liver enzymes are no longer reliable markers, and how noninvasive tools like…
12 Mar 2026 · 8 min
Monitoring & Follow Up of Patients With CHB
In this educational video, Dr. Kimberly Brown, transplant hepatologist at Henry Ford Hospital, reviews key strategies for monitoring and managing patients with chronic hepatitis B in clinical practice. She outlines the primary goals of treatment—preventing progression to cirrhosis, liver cancer, liver failure, and transplantation while also reducing the risk of viral transmission. The discussion highlights updated AASLD hepatitis B guidance, including how clinicians identify patients who require treatment and how to monitor those considered inactive carriers through regular laboratory…
10 Feb 2026 · 11 min
What Are the Current Strategies for Managing Pruritus in Patients With PBC?
In this educational video, Christopher Bowlus, MD, the Chief of Gastroenterology at the University of California Davis and Lena Valente Professor, provides a comprehensive overview of current pharmacologic and non-pharmacologic strategies for managing pruritus (itch) in patients with Primary Biliary Cholangitis (PBC). He explains why pruritus is one of the most common and under recognized symptoms of PBC, affecting up to 80% of patients, and highlights the importance of proactively asking patients about itch using validated tools such as the Numeric Rating Scale (NRS). The discussion…
10 Feb 2026 · 10 min
What Special Considerations Should Be Taken While Managing PBC in Pregnant Patients?
In this video, Aparna Goel, MD, associate professor of medicine at Stanford University, reviews the impact of pregnancy on primary biliary cholangitis (PBC) and key considerations for managing pregnant patients with autoimmune liver disease. The discussion covers how pregnancy affects PBC laboratory markers, including the limitations of alkaline phosphatase as a biomarker, common symptom changes such as worsening pruritus, and the importance of monitoring bile acids, liver enzymes, and fat-soluble vitamins. Medication safety during pregnancy, including continued use of ursodeoxycholic acid,…
2 Feb 2026 · 14 min
Pathophysiology and Overview of Hepatitis B
In this overview, Tatyana Kushner, MD, reviews key aspects of hepatitis B pathophysiology with a focus on covalently closed circular DNA (cccDNA) and its role in viral persistence and barriers to cure. She explains how cccDNA is established and maintained within hepatocytes, how host epigenetic regulation influences viral transcription, and why current antiviral therapies are unable to eliminate cccDNA. The discussion highlights emerging cure strategies, including epigenetic silencing, direct cccDNA targeting, gene-editing technologies, and host factor modulation. Dr. Kushner also explores…
6 Oct 2025 · 6 min
Patient Centric Care Approaches in CHB
In this episode, Dr. Robert Wong from Stanford University School of Medicine discusses the importance of patient-centered care and the role of patient-reported outcomes in the comprehensive management of chronic hepatitis B. Dr. Wong explains how PROs capture patients’ perspectives on their physical, mental, and social well-being—critical yet often underrecognized components of care. He highlights three validated tools that can be easily integrated into clinical practice: the Short Form-36 (SF-36), the Chronic Liver Disease Questionnaire (CLDQ), and the Work Productivity and Activity…
6 Oct 2025 · 7 min
Patient Centric Care Approaches in PBC
In this episode, Dr. Robert Wong from the Division of Gastroenterology and Hepatology at Stanford University School of Medicine discusses the value of patient-centric care and patient-reported outcomes in managing Primary Biliary Cholangitis (PBC). While traditional care often focuses on liver function tests and biochemical markers like alkaline phosphatase, Dr. Wong emphasizes the equal importance of understanding how PBC impacts a patient’s daily life, mental health, and overall quality of life. He highlights the PBC-40 questionnaire, a validated tool that captures six key domains—fatigue,…
22 Sep 2025 · 10 min
Education & Engagement for CHB Patients
In this expert discussion, Dr. Paul Kwo, hepatologist at Stanford University, explores the critical importance of patient adherence to treatment for chronic hepatitis B. Hepatitis B remains a global public health challenge and a leading cause of liver cancer—and yet in the U.S., many individuals remain undiagnosed or untreated. Dr. Kwo outlines how to assess disease stage, when to initiate antiviral therapy, and how to communicate effectively with patients—especially foreign-born individuals—about the safety, effectiveness, and accessibility of approved treatments. He explains how these…
22 Sep 2025 · 15 min
Introduction to Understanding Hepatitis B
Join Dr. Ira Jacobson, Professor of Medicine at NYU Langone Health, for an in-depth exploration of the complex pathophysiology of chronic hepatitis B. In this expert lecture, Dr. Jacobson reviews the virologic and immunologic mechanisms that underpin HBV infection, from viral entry into hepatocytes and the formation of covalently closed circular DNA (cccDNA), to the integration of viral DNA and its implications for hepatocellular carcinoma. He also examines the immune system’s multifaceted role in disease progression, including T-cell exhaustion, checkpoint inhibition, and the contributions…
22 Sep 2025 · 7 min
Quantitative HBsAg Testing in CHB Patients
In this expert video, Dr. Robert Gish—renowned hepatologist and Medical Director of the Hepatitis B Foundation—discusses the critical role of quantitative hepatitis B surface antigen (HBsAg) testing in the management and long-term monitoring of chronic hepatitis B. With over a decade of experience using quantitative HBsAg in clinical practice, Dr. Gish explains how this highly sensitive test complements HBV DNA and e-antigen testing to assess disease phase, track treatment response, and evaluate a patient's candidacy for functional cure. He breaks down how low surface antigen levels can…
11 Sep 2025 · 4 min
Monitoring and Follow Up of Patients With PBC
In this expert highlight, Dr. Robert Wong shares essential tips for monitoring and managing patients with Primary Biliary Cholangitis (PBC). He outlines key goals after diagnosis, including evaluating liver disease severity through imaging and lab-based non-invasive testing, and assessing treatment eligibility. Dr. Wong explains the importance of monitoring alkaline phosphatase (ALP) levels—not only to guide treatment initiation but also to measure treatment response, with normalization signaling a complete response. Beyond labs, he emphasizes the need to assess patient-reported outcomes…
11 Sep 2025 · 8 min
Guideline Implementation for PBC Patients
Join Dr. Alan Bonder, Associate Professor of Medicine at Harvard Medical School and Medical Director of Liver Transplantation, for an expert overview on the latest AASLD guideline updates for Primary Biliary Cholangitis (PBC). This in-depth session highlights key diagnostic criteria—such as AMA positivity, elevated alkaline phosphatase, and histologic confirmation—and walks through evidence-based treatment pathways for managing PBC. Dr. Bonder discusses the pivotal role of ursodeoxycholic acid (UDCA) as first-line therapy and emphasizes the importance of risk stratification using tools like…
7 Aug 2025 · 4 min
Diet and Lifestyle Modifications in PBC: What Can We Recommend to Our Patients?
Thank you Gilead Sciences, Inc. for your support on this FAQ Video Module. In this practical and patient-focused video, Dr. Nadege Gunn, a hepatologist based in Waco, Texas, shares essential diet and lifestyle strategies for individuals living with Primary Biliary Cholangitis (PBC). Addressing a common question—“What can I eat or do to feel better?”—Dr. Gunn highlights the benefits of a balanced, Mediterranean-style diet rich in fruits, vegetables, nuts, seeds, fish, and olive oil. She emphasizes bone health as a key concern for PBC patients, recommending adequate intake of vitamin D and…
5 Aug 2025 · 2 min
The Psychological Impact of PBC: Addressing Mental Health in Our Patients
Thank you Gilead Sciences, Inc. for your support on this FAQ Video Module. In this thoughtful discussion, Dr. Nancy Reau from RUSH University Medical Center explores the often-overlooked psychological impact of Primary Biliary Cholangitis (PBC). While managing the physical symptoms of PBC is critical, addressing the emotional and mental health challenges faced by patients is equally important. Dr. Reau highlights how the lifelong nature of PBC, its familial implications, unpredictable progression, and extrahepatic symptoms like fatigue and pruritus can contribute to significant stress,…
31 Jul 2025 · 6 min
How Can We Overcome Barriers to Treatment Adherence in PBC?
Thank you Gilead Sciences, Inc. for your support on this FAQ Video Module. In this insightful discussion, Dr. Tatyana Kushner, hepatologist and associate professor at Weill Cornell Medicine, explores the critical issue of medication adherence in patients living with Primary Biliary Cholangitis (PBC). While ursodeoxycholic acid (ursodiol) remains the cornerstone of first-line therapy for PBC, up to half of patients express uncertainty or reluctance about taking it consistently. Dr. Kushner delves into the complex barriers affecting adherence, including lack of symptom relief, fear of side…

About CLDF Podcast

The official podcast channel for the Chronic Liver Disease Foundation.

CLDF Podcast is a English health podcast from Chronic Liver Disease Foundation. Melo plays each episode straight from the publisher's own feed — no ads added, no account needed — and remembers where you stopped, in this browser only.

Publisher: Chronic Liver Disease Foundation
Language: English
Category: Health
New episodes: Weekly
Typical length: 10 min
Latest episode: 24 Sep 2026
Feed: RSS — paste into any podcast app
Apple Podcasts: podcasts.apple.com/podcast/id1757840932

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