Retatrutide Phase 3 Results: What the Data Actually Means

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1. 

   E159 · 22 Sep 2026 · 49 min

   Food Noise Is Real, and Now We Can Measure It

   Obesity researchers Dr. David Allison and Dr. Emily Dhurandhar explain how they defined and built a validated questionnaire for food noise, the persistent and distressing thoughts about food that many patients say disappear on GLP-1 medications. They break down how food noise differs from hunger and cravings, where the research is going next, and why the term came from patients, not pharmaceutical companies. A quick check: the transcript never states the questionnaire's official name, so I kept it generic. If it has a published title or acronym, dropping it into the description would help…

2. 

   E158 · 30 Aug 2026 · 48 min

   Does Metabolically Healthy Obesity Even Exist?

   Dr. Christian Rodriguez unpacks his review on metabolically healthy obesity, showing why the concept is mostly a temporary phase rather than a stable protective state. He and the hosts compare the new Lancet Commission obesity criteria against the ACE staging system, then debate GLP-1 stigma and the ethics of treating obesity before it turns severe.

3. 

   E157 · 3 Aug 2026 · 40 min

   Is Your Obesity Genetic? Food Noise and Bardet-Biedl Syndrome Explained

   Is severe, insatiable hunger a failure of willpower or hardcoded into your biology? In this episode of Docs Who Lift, Dr. Spencer and Dr. Karl Nadolsky speak with obesity specialist Dr. Jesse Richards to uncover Bardet-Biedl Syndrome (BBS), the updated 2024 diagnostic criteria, and how targeted therapies offer hope when standard GLP-1s and willpower aren't enough.

4. 

   E156 · 7 Jul 2026 · 37 min

   PCOS Renamed to PMOS? Here's Why and What Changes for You

   Dr. Spencer Nadolsky and Karl sit down with Dr. Susan Brian to break down one of the most significant proposed changes in women's health in decades, the potential renaming and reclassification of polycystic ovarian syndrome to anovulatory androgen excess, and what that shift means for the millions of women who have been diagnosed, misdiagnosed, or dismissed under the current framework.

5. 

   E155 · 17 Jun 2026 · 57 min

   Are Peptides the New Snake Oil? What the Actual Science Says With Barbell Medicine

   Dr. Spencer Nadolsky and Karl bring on Dr. Austin Baraki and Dr. Jordan Feigenbaum from Barbell Medicine to cut through the peptide hype and explain why most of the research peptides people are currently injecting have no randomized controlled trial data in humans, were abandoned by pharmaceutical companies because they failed or showed harm signals, and may not even contain what is on the label. The core message is simple: calling something a short chain amino acids does not make it safe, natural does not mean studied, and having a standard of evidence before putting something in your body…

6. 

   E153 · 25 May 2026 · 40 min

   GLP-1 Maintenance: What Happens When You Lower Your Dose, Switch Medications, or Stop Entirely

   2:26 PMClaude responded: Dr.Dr. Spencer Nadolsky and Karl break down two brand new randomized controlled trials, Surmount-Maintain and Attain-Maintain, that put hard numbers on what actually happens to patients when they try to lower their tirzepatide dose, switch to oral orforglipron, or come off GLP-1 medicines entirely after significant weight loss. The data confirms what they have been seeing clinically for years: obesity biology fights hard to pull weight back up, only about 17 percent of people can come off these medicines and maintain their results, and for most patients the…

7. 

   E152 · 18 May 2026 · 32 min

   Are GLP-1 Medicines Shredding Your Bones? Here Is What the Actual Evidence Says With Dr. Susan Brian

   Dr. Spencer Nadolsky and Karl sit down with Dr. Susan Brian, a Yale-trained endocrinologist and certified menopause provider who runs a bone fragility fracture clinic, to break down whether GLP-1 medicines are actually causing bone loss or whether the viral panic around this topic is getting ahead of the evidence. The short answer is that the medicines themselves do not appear to be the problem, the weight loss is, and there is a clear and well-established playbook for protecting your bones while on them.

8. 

   E151 · 5 May 2026 · 53 min

   Heavy Metal Toxicity: Separating Real Risks From Influencer Scams | Dr. Eryn Russo

   Dr. Spencer Nadolsky and Karl sit down with Dr. Eryn Russo, a board-certified occupational and environmental medicine physician with nearly 20 years of experience treating real toxic metal exposures, to break down exactly why the heavy metal detox industry is built on tests that are not supported by any medical standard and treatments that can cause genuine harm. If an influencer has ever made you wonder whether lead, mercury, or cadmium is behind your symptoms, this is the episode that puts that fear to rest with actual science.

9. 

   E150 · 21 Apr 2026 · 25 min

   GLP-1 Genetics: Predicting Weight Loss and Side Effects With 23andMe's Dr. Adam Auton

   Dr. Spencer Nadolsky and Karl sit down with Dr. Adam Auton, geneticist at 23andMe, to break down a brand new paper using data from over 27,000 people that identified specific genetic variants in the GLP-1 receptor and GIP receptor that predict both how much weight someone loses on these medications and how likely they are to experience side effects. This is one of the first studies to show that precision medicine for GLP-1 drugs may already be closer than most people think.

10. 

    E149 · 14 Apr 2026 · 36 min

    Do GLP-1 Medicines Actually Cause Muscle Loss? New Research With Dr. Henning Langer

    Dr. Spencer Nadolsky and Karl sit down with Dr. Henning Langer, a PhD researcher at the Charité in Berlin, to break down his newly published paper combining rodent and human data to look directly at what GLP-1 medicines actually do to skeletal muscle beyond what a DEXA scan can tell you. From mice running to exhaustion on semaglutide to maximum voluntary contraction data in humans, this is the most granular conversation yet on whether these drugs are doing something to muscle that nobody fully understands yet.