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1. 

   S5 · E230 · 23 Apr 2026 · 25 min

   230: Same Gram Stain, Different Story: Neisseria meningitidis vs gonorrhoeae

   In this week's episode, we continue our series on gram-negative cocci and take a closer look at two of the most important organisms: Neisseria meningitidis and Neisseria gonorrhoeae. On the Gram stain, they may look the same—but clinically, they represent very different scenarios. We walk through colonization, transmission, and key virulence factors, and connect them to the infections they cause—from meningitis and invasive disease to mucosal and disseminated gonococcal infections. We also bring it back to the bench, discussing specimen source, testing approaches like NAAT and culture, and…

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   S5 · E229 · 16 Apr 2026 · 26 min

   229: Gram-Negative Cocci: Beyond the Plate

   In this episode we continue our gram-negative cocci series by moving beyond the plate and into modern identification methods. From traditional systems like VITEK and RapID NH to MALDI-TOF and molecular testing, we explore how these organisms are identified in today's clinical microbiology lab. We also break down the role of NAATs and syndromic panels in detecting organisms like Neisseria meningitidis and Neisseria gonorrhoeae, especially in situations where culture may be delayed or negative. This episode focuses on how these tools fit into real-world workflows—highlighting their advantages,…

3. 

   S5 · E228 · 9 Apr 2026 · 28 min

   228: Gram-Negative Cocci: What to Do After the Gram Stain

   In this episode of Let's Talk Micro, we continue our gram-negative cocci series by focusing on what to do after the Gram stain. You've identified gram-negative cocci—now what? We take a practical, bench-focused approach to working these organisms up, covering key culture media like blood agar, chocolate agar, and selective media such as Modified Thayer-Martin and Martin-Lewis. We also review collection and transport considerations, including JEMBEC and CO₂ requirements for Neisseria gonorrhoeae . We then dive into commonly used tests, including ONPG for differentiating Neisseria lactamica…

4. 

   S5 · E227 · 2 Apr 2026 · 20 min

   227: When Gram-Negative Cocci Show Up: How to Think at the Bench

   In this episode of Let's Talk Micro, we kick off a new series on gram-negative cocci by starting where it all begins—the Gram stain. Seeing gram-negative diplococci on a smear can feel intimidating, especially when you're on the bench and need to make the right call. In this episode, we focus on how to approach that moment with confidence. We walk through the key organisms you'll encounter, including Neisseria, Moraxella, and Veillonella, and discuss how morphology, specimen source, and clinical context all come together to guide your thinking. We also revisit a correction from a previous…

5. 

   S5 · E226 · 26 Mar 2026 · 39 min

   226: CLSI M100 2026 Updates

   The CLSI M100 gets updated every year—but what do those changes actually mean for the microbiology lab? In this episode of Let's Talk Micro, Luis is joined by Dr. April Bobenchik to break down the latest updates in the CLSI M100 2026 (36th edition) and how they translate into real-world lab practice. They walk through important breakpoint changes, including aztreonam–avibactam and updates for Acinetobacter , along with new additions like trimethoprim-sulfamethoxazole breakpoints for beta-hemolytic streptococci. Another notable update this year is the updated anaerobic antibiogram and how it…

6. 

   S5 · E225 · 6 Mar 2026 · 57 min

   225: Too Many Bugs, One Culture: A CMPH Guide to Wound Cultures

   Wound cultures are some of the most complex specimens encountered in the clinical microbiology laboratory. Unlike more straightforward cultures, wound specimens often contain multiple organisms, making it challenging to determine which microbes are clinically significant and which represent colonization. In this episode of Let's Talk Micro, Luis is joined by Dr. Christopher Doern and Dr. Alexandra Bryson to discuss the wound culture guidelines from the Clinical Microbiology Procedures Handbook (CMPH) and how they can help laboratorians navigate these challenging cultures. Together, they…

7. 

   S5 · E224 · 27 Feb 2026 · 14 min

   224: Micro Minutes: Sometimes Gram Stains Lie

   The Gram stain is one of the most trusted tools in clinical microbiology—but it doesn't always tell the full story. In this Micro Minutes episode, we break down why Gram stains can sometimes be misleading and how factors like culture age, antibiotic exposure, decolorization, morphology, and arrangement can change what you see under the microscope. We also touch on classic troublemakers like Acinetobacter and tiny coccobacilli such as Pasteurella and Haemophilus, and how careful observation can keep you from jumping to the wrong conclusion. Short, focused, and straight from the bench—this…

8. 

   S5 · E223 · 20 Feb 2026 · 52 min

   223: SuperStat to Storytime: Building the Future of Laboratory Medicine

   In this episode of Let's Talk Micro, we step beyond the microbiology bench to talk laboratory medicine, advocacy, and storytelling with fellow medical laboratory scientists and podcasters Stephanie Whitehead and Aaron Odegard. We explore how their work on the SuperStat Podcast is helping amplify the voice of the laboratory through conversations on leadership, access, and visibility. The discussion also highlights Little Lab Learners: ABCs of Laboratory Medicine, a children's book created to introduce laboratory medicine early and inspire future lab professionals. Together, we talk about lab…

9. 

   S5 · E222 · 13 Feb 2026 · 49 min

   222: Parasites, Pediatrics, and the Lab: A Study from Guinea, West Africa

   In this episode of Let's Talk Micro, Luis is joined by Dr. Joel Mortensen to discuss a study examining intestinal parasites in pediatric patients in Guinea, West Africa. They dive into the real-world challenges of diagnosing parasitic infections in resource-limited settings, including reliance on stool microscopy, the use of rapid antigen tests, and how seasonal changes influence infection rates. Dr. Mortensen walks us through the study design, key findings, and what the data revealed about protozoal infections, as well as the role of microscopy in identifying helminths in this setting. This…

10. 

    S5 · E221 · 6 Feb 2026 · 36 min

    221: Beyond the Plate: Your Isolates and Genomic Epidemiology

    Genomic epidemiology is reshaping how we detect, investigate, and control infectious disease outbreaks—but what does that actually look like from the bench to public health? In this episode of Let's Talk Micro, Luis is joined by genomic epidemiologist Krisandra Allen for a practical, case-based conversation on how pathogen sequencing data is generated, analyzed, and paired with epidemiologic information to answer questions traditional methods can't. They discuss foodborne and hepatitis A outbreaks, geographically dispersed clusters, and how sequencing is being integrated into routine public…