Podcast · Health

Lifespan with Dr. David Sinclair

by Lifespan Communications LLC · English · Health

New episodes: Weekly
Typical length: 1 hr 8 min
Latest: 4 Oct 2026
Language: English

Latest episode

4 Oct 2026 · 1 hr 1 min

Are GLP-1s the First Longevity Drugs? | Lifespan with Dr. David Sinclair - S2, Ep. 11

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ Ozempic and GLP-1s transformed weight loss. Could they also extend lifespan? In this episode, David and Matt look at the emerging science behind that question. They examine a recent study in which semaglutide…

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Earlier episodes 21 most recent

19 Sep 2026 · 49 min

This Sugar Substitute May Extend Your Life | Lifespan with Dr. David Sinclair - S2, Ep. 9

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ Could an amino acid sweet enough to replace sugar also help us live longer? In this episode, David and Matt explore Glycine, one of life’s simplest building blocks, and why it’s attracting attention in aging…
11 Sep 2026 · 31 min

How to Eat for Gut Health & Longevity | Lifespan with Dr. David Sinclair - S2, Ep. 8

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This Lifespan episode explores how what we eat shapes how we age - from inflammation and blood sugar to the trillions of microbes living in our gut. Dr. Sinclair explains how diet affects key biological processes…
4 Sep 2026 · 31 min

Why We Age | Lifespan with Dr. David Sinclair - S2, Ep. 7

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and longevity scientist - and co-host Matthew LaPlante explore why we age, how aging begins long…
21 Aug 2026 · 1 hr 11 min

Why Exercise Slows Aging | Lifespan with Dr. David Sinclair

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ This episode explores why humans are biologically built to move and what happens to the aging process when we don’t. Drawing on evolutionary biology and the latest research, Dr. Sinclair traces physical activity…
7 Aug 2026 · 1 hr 9 min

How to Exercise to Live Longer | Lifespan with Dr. David Sinclair - S2, Ep. 5

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and longevity scientist – details how to exercise for a longer, healthier life. Drawing on the latest…
S2 · E4 · 23 Jul 2026 · 1 hr 12 min

Inside the World’s First Age Reversal Trial | Lifespan with Dr. David Sinclair - S2, Ep. 4

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of eye aging, vision loss, and emerging…
12 Jul 2026 · 1 hr 8 min

What to Eat & When to Eat for Longevity: New Science | Lifespan with Dr. David Sinclair - S2, Ep. 3

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives - while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this second installment of Lifespan's two-part series on calorie restriction and fasting, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and a pioneer in longevity research…
25 Jun 2026 · 1 hr 15 min

Fasting as a Path to Longevity: The Facts | Lifespan with Dr. David Sinclair - Season 2, Episode 2

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. – Professor of Genetics at Harvard Medical School and pioneer in longevity research – explores the science of calorie restriction and fasting,…
S2 · E1 · 25 Jun 2026 · 1 hr 6 min

The Longevity Revolution Is Here | Lifespan with Dr. David Sinclair - Season 2, Episode 1

At Lifespan, our mission is to help you and your loved ones live your longest, healthiest lives while supporting medical research into breakthroughs to improve all lives. We’re building the world’s largest longevity community: Join us at https://lifespan.com. Follow us on YouTube, Apple, and Spotify for new Lifespan episodes every 2 weeks. __________________________________________ In this first episode of Lifespan Season 2, Dr. David Sinclair, A.O., Ph.D. - Professor of Genetics at Harvard Medical School and pioneer in longevity research - returns and explores one of the most consequential…
21 May 2026 · 1 hr 16 min

The Most Surprising Longevity Discoveries | Lifespan with Dr. David Sinclair Rewind

What are the most important things you can do today to live longer and stay healthier while doing it? In this final Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most surprising insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a thought-provoking, focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application.…
18 May 2026 · 2 min

Season 2 Official Trailer: Lifespan with Dr. David Sinclair

What if aging is more reversible than we once thought? Season 2 of Lifespan with Dr. David Sinclair, A.O., Ph.D., explores the latest breakthroughs in longevity science - from epigenetic restoration to fasting, exercise, sleep, metabolism, and the emerging technologies that could help us live longer and healthier lives. Drawing on more than 30 years of research and conversations at the frontier of science and medicine, Dr. Sinclair breaks down complex discoveries into practical, evidence-based insights designed to help you understand how the body ages - and what may be possible to slow,…
6 May 2026 · 59 min

What To Do For Longevity | Lifespan with Dr. David Sinclair Rewind

What are the most important things you can do today to live longer and stay healthier while doing it? In this first Lifespan Rewind episode, Dr. David Sinclair, A.O., Ph.D., a Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, revisits the most impactful insights from his #1-ranked Season 1 series, combining updated commentary with key moments from across all eight episodes. The result is a focused, practical guide to the science of longevity – grounded in evidence and designed for real-world application. This episode covers:…
S1 · E8 · 23 Feb 2022 · 1 hr 9 min

Biotracking, Age Reversal & Other Advanced Health Technologies | Episode 8

In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies that successfully extend healthspan and/or lifespan are also considered. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Our…
S1 · E7 · 16 Feb 2022 · 1 hr 2 min

The Science of Keeping the Brain Healthy | Episode 7

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker -…
S1 · E6 · 9 Feb 2022 · 1 hr 10 min

The Science of Looking Younger, Longer | Episode 6

In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, including newer interventions like low-level laser therapy and platelet-rich plasma injections. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair Levels - https://levels.link/sinclair InsideTracker -…
S1 · E5 · 2 Feb 2022 · 59 min

Medical Interventions (TRT, HGH, Stem Cells, Peptides, etc.) For Longevity | Episode 5

In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed. Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels -…
S1 · E4 · 26 Jan 2022 · 1 hr 10 min

NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4

In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a special focus is placed on the NAD precursors nicotinamide riboside and nicotinamide mononucleotide. Known mechanisms, limitations, and/or side effects associated with these molecules are additionally highlighted. Correction and clarification: At…
S1 · E3 · 19 Jan 2022 · 1 hr 11 min

Exercise, Heat, Cold & Other Stressors for Longevity | Episode 3

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these…
S1 · E2 · 12 Jan 2022 · 1 hr 8 min

What to Eat & When to Eat for Longevity | Episode 2

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the benefits of a mostly plant-based diet for slowing aging and offer key insights into when to eat and what to eat to maximize longevity. Thank you to our sponsors: Levels - https://levels.link/sinclair Athletic Greens -…
S1 · E1 · 5 Jan 2022 · 1 hr 2 min

The Science Behind Why We Age | Episode 1

In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks. Thank you to our sponsors: Athletic Greens -…
22 Dec 2021 · 1 min

Welcome to Lifespan with Dr. David Sinclair

Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and February 2022. This podcast can also be found on YouTube: https://www.youtube.com/davidsinclairpodcast My goal in creating this podcast is to discuss the science behind why we age and to share the newest research on what we can do to slow, stop and even…

About Lifespan with Dr. David Sinclair

Lifespan with Dr. David Sinclair is a health and science show on how to live longer and stay healthier - grounded in the latest longevity research. A Professor of Genetics for over 25 years at Harvard Medical School and a leader in the field of longevity research, Dr. Sinclair breaks down the latest studies into clear, applicable insights so that you can perform at your best and live your longest, healthiest life. Season 1 ranked #1 in Health & Wellness podcasts. Season 2 is now live, starting with two Rewind episodes, followed by new episodes detailing the latest breakthroughs in aging science. Become a Lifespan member at lifespan.com. New episodes every two weeks.

Lifespan with Dr. David Sinclair is a English health podcast from Lifespan Communications LLC. Melo plays each episode straight from the publisher's own feed — no ads added, no account needed — and remembers where you stopped, in this browser only.

Publisher: Lifespan Communications LLC
Language: English
Category: Health
New episodes: Weekly
Typical length: 1 hr 8 min
Latest episode: 4 Oct 2026
Feed: RSS — paste into any podcast app
Apple Podcasts: podcasts.apple.com/podcast/id1601709306
Rights: Lifespan Communications LLC

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