Karl Pfleger Explains the Aging Biotech Explosion

More from Longevity by Design All episodes →

1. 

   S1 · E96 · 8 Oct 2025 · 1 hr

   Building a Blueprint for Longer Lives Through Public Policy

   In this episode of Longevity by Design, our host, Dr. Gil Blander, sits down with Dylan Livingston, CEO at the Alliance for Longevity Initiatives, and Dr. Brenda Eap to explore how public policy shapes the future of aging research. Dylan and Brendan share how their team pushes for legislation that supports healthy lifespan extension, aiming to bring longevity science into the center of national health priorities. Dylan and Brendan explain why policy advocacy is crucial for securing funding f...

2. 

   S1 · E95 · 17 Sep 2025 · 1 hr 7 min

   Dr. Peter Fedichev: Why Aging Is Functional Decline, Not Just Disease

   Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a...

3. 

   S1 · E94 · 3 Sep 2025 · 53 min

   Dr. Eric Verdin on the Effects of Therapeutic Plasma Exchange on Longevity

   In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks. Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept insp...

4. 

   S1 · E93 · 20 Aug 2025 · 1 hr 5 min

   What Happens to Your Body When You Sit All Day, with Dr. Keith Diaz

   In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting. Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his lab's findings, he shares a simple but powerful prescription: five minutes of light walking every hour. That small change can lower blood pressure, ...

5. 

   S1 · E92 · 6 Aug 2025 · 56 min

   Acetylation Insights: Unlocking Longevity Secrets with Dr. Haim Cohen

   In this episode, Dr. Gil Blander welcomes Dr. Haim Cohen to Longevity by Design to explore his revolutionary approach to understanding aging. Haim's team analyzed acetylation sites across 107 mammalian species, creating its most extensive comparative study. This computational approach revealed specific post-translational modifications that evolved exclusively in long-lived animals. The research identifies critical pathways where evolution engineered longevity solutions. These acetylation cha...

6. 

   S1 · E90 · 9 Jul 2025 · 1 hr 13 min

   How to Extend Your Healthspan with Dr. Eric Topol

   Gil and Eric discuss Eric’s book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide personalized recommendations for preventing age-related diseases. The conversation also explores the importance of exercise, sleep, and social conne...

7. 

   S1 · E89 · 18 Jun 2025 · 1 hr 19 min

   The Science of Muscle, Protein, and Longevity: Insights from Dr. Layne Norton

   In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stresses the power of personalized approaches to nutrition and fitness, advocating for a critical approach to information consumption. Layne dives int...

8. 

   4 Jun 2025 · 57 min

   Beyond Sick Care: Evelyne Bischof on the Rise of Longevity Medicine

   On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society. Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizing health span, not just lifespan, and how healthy longevity medicine benefits not only individuals, but population health and the world econ...

9. 

   21 May 2025 · 51 min

   Precision Habits: How Wearables and AI Are Powering Personalized Longevity

   In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity. The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a ...

10. 

    7 May 2025 · 1 hr 22 min

    Scanning the Future: How Whole-Body MRI is Transforming Longevity with Dr. Daniel Durand

    Dr. Gil Blander welcomes Dr. Daniel Durand, Chief Medical Officer at Prenuvo, to Longevity by Design for a deep dive into the future of preventative healthcare. Dr. Durand shares how full-body MRI is redefining early detection by making advanced imaging accessible, non-invasive, and radiation-free. He explains why MRI, as a soft tissue imaging modality, offers unmatched insight into early-stage cancers and chronic conditions. The conversation unpacks misconceptions around overdiagnosis and f...