13 Oct 2026 · 33 minNew
Lecture 9 - multiplicity
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
Podcast · Tech & Science
Sensible Medicine
by Sensible Medicine Authors and Editors · English · Tech & Science
Common sense and original thinking in bio-medicine A platform for diverse views and debate www.sensible-med.com
- New episodes
- Weekly
- Typical length
- 37 min
- Latest
- 13 Oct 2026
- Language
- English
Latest episode
Earlier episodes 29 most recent
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7 Oct 2026 · 39 min
This Fortnight in Medicine XXXV
Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy * The Hubris of Screening for Disease — Again Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment * Why Blood Tests Are a Poor Screening Tool for Alzheimer’s This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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23 Sep 2026 · 32 min
This Fortnight in Medicine XXXIV
Cancer-Related Mortality Among US Pilots and Flight Attendants Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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22 Sep 2026 · 20 min
Lecture 8 - endpoints
Our free series is almost over This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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15 Sep 2026 · 30 min
Lecture 7
New lectures coming soon (after part 9) This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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11 Sep 2026 · 10 min
Friday Reflection 63: Foxes, Hedgehogs, Generalists, and Specialists
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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9 Sep 2026 · 10 min
Fortnight in medicine
A royal mistake This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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8 Sep 2026 · 35 min
Lecture 6 KM Curves
we are making all the old episodes available for free, and then on to the new ones -v This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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1 Sep 2026 · 43 min
Lecture 5
New episodes coming soon. First 9 parts free now. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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26 Aug 2026 · 51 min
This Fortnight in Medicine XXXIII
Coronary-Artery Revascularization before Elective Major Vascular Surgery Discontinuation of statins for primary prevention of atherosclerotic cardiovascular disease in adults aged 75 years or older (SAGA/SITE): a multicentre, open-label, pragmatic, non-inferiority randomised trial This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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25 Aug 2026 · 37 min
Lecture 4 - How not to be fooled
I notice that someone was angry that we are re-posting old episodes BEFORE we post the new ones. Just a reminder, we said we would do this! We will make the old ones available for free, and then post the new ones. Bear with us. In the meantime, enjoy. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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18 Aug 2026 · 35 min
Lecture 3: How Not to Be Fooled - VP's Intro
And here is lecture 3 of How Not to Be Fooled series 19 parts coming! 9 for free, and 10 for subscribers. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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12 Aug 2026 · 46 min
This Fortnight in Medicine XXXII
Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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29 Jul 2026 · 42 min
This Fortnight in Medicine XXXI
Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men A Randomized Clinical Trial * Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment Cost-Effectiveness of Fecal Immunochemical Testing Alone vs Co-Testing With Helicobacter pylori Stool Antigen This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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15 Jul 2026 · 45 min
This Fortnight in Medicine XXX
Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial John Mandrola: I am torn on the PolyPill concept This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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1 Jul 2026 · 37 min
This Fortnight in Medicine XXIX
Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia * Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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26 Jun 2026 · 5 min
Friday Reflection 62: The Ethics of Telling Patients We Have Nothing Left to Offer
TR is an 88-year-old man who is disabled and in chronic pain from spinal stenosis and knee osteoarthritis. He has multiple other medical issues, including coronary artery disease and COPD. He has been through years of treatment for his knees and back, including physical therapy, multiple joint injections, and an in-office procedure for spinal stenosis. He has been on multiple regimens of oral pain medications. He is not interested in surgery (and probably would not be considered a reasonable candidate if he were). He comes to a visit and asks what can be done. Sensible Medicine is a…
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17 Jun 2026 · 32 min
This Fortnight in Medicine XXVIII
Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults * Prespecified Falsification End Points: Can They Validate True Observational Associations? * Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis GLP-1 receptor agonist use and cancer risk in obese nondiabetic adults * Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists: A Systematic Review and Meta-analysis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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3 Jun 2026 · 33 min
This Fortnight in Medicine XXVII
Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up GLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy * Previously discussed on Fornight XXII: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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20 May 2026 · 55 min
This Fortnight in Medicine XXVI
Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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6 May 2026 · 30 min
This Fortnight in Medicine XXV
Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients * Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage * Effect of Combination Therapy on Adherence Among US Patients Initiating Therapy for Hypertension: a Cohort Study This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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22 Apr 2026 · 46 min
This Fortnight in Medicine XXIV
RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism * Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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8 Apr 2026 · 34 min
This Fortnight in Medicine XXIII
Dengue Suppression by Male Wolbachia-Infected Mosquitoes * World Mosquito Program Antibiotic Therapy for Uncomplicated Acute Appendicitis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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24 Mar 2026 · 40 min
This Fortnight in Medicine XXII
* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study * Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction * Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI And, a bunch of the other studies we discussed. * Complete Revascularization with Multivessel PCI for Myocardial Infarction * FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction * Initial Invasive or Conservative Strategy for Stable…
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11 Mar 2026 · 36 min
This Fortnight in Medicine XXI
Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study * A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools * Why Are So Many Teen Girls Still Tearing Their A.C.L.s? * Injury prevention programs that include plyometric exercises reduce the incidence of anterior cruciate ligament injury: a systematic review of cluster randomised trials This is a public episode. If you'd like to discuss this…
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4 Mar 2026 · 24 min
Going Beyond "AI in Medicine"
Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected. Dr. Shantanu Nundy, MD, MBA, is a practicing physician whom I like to think of as a serial innovator. He is currently an advisor on artificial intelligence to the FDA in the Commissioner’s Office. He has spent a great deal of time and energy thinking deeply about what AI can bring us today and in the future. I hope you enjoy…
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25 Feb 2026 · 39 min
This Fortnight in Medicine XX
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults * High-Dose Influenza Vaccine to Reduce Hospitalizations * Efficacy of high-dose versus standard-dose influenza vaccine in older adults Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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18 Feb 2026 · 37 min
Alternative Modalities for Breast Cancer Screening
Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing gender-based care. Dr. Rusiecki and I discussed the article appraised in the other post today, and also discussed the issues of screening for breast cancer in women with dense breasts and breast cancer screening more generally. Dr. Rusieki and I don’t agree on everything, and you might leave more confused…
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11 Feb 2026 · 45 min
This Fortnight in Medicine XIX
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction * Should Evidence Come with an Expiration Date? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
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28 Jan 2026 · 46 min
This Fortnight in Medicine XVIII
No video this week — we had a bit of a computer meltdown — but two interesting articles. As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at [email protected]. This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe
About Sensible Medicine
Common sense and original thinking in bio-medicine A platform for diverse views and debate www.sensible-med.com
Sensible Medicine is a English tech & science podcast from Sensible Medicine Authors and Editors. Melo plays each episode straight from the publisher's own feed — no ads added, no account needed — and remembers where you stopped, in this browser only.
- Publisher
- Sensible Medicine Authors and Editors
- Language
- English
- Category
- Tech & Science
- New episodes
- Weekly
- Typical length
- 37 min
- Latest episode
- 13 Oct 2026
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- podcasts.apple.com/podcast/id1667709917
- Rights
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