Constructing and Judging Modern Agentic Workflows

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1. 

   E305 · 31 Jul 2026 · 57 min

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   E304 · 24 Jul 2026 · 58 min

   Configuring a Versatile LLM Harness & Scraping the Web With Scrapy

   Which is more important, the model or the "harness" around an LLM? What are ways to assemble an efficient agentic developer workflow? This week on the show, Ayan Pahwa joins us to discuss harnessing, web scraping, and self-hosting Python applications.

3. 

   E303 · 17 Jul 2026 · 51 min

   Free-Threaded Python's History & uv in Production

   How many attempts have been made to remove Python's Global Interpreter Lock (GIL)? How do they compare to the current approach? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

4. 

   E301 · 3 Jul 2026 · 46 min

   Running Python Locally in a Sandbox

   How do you avoid the risk of running a Python application locally that could be malicious, break your code, or leak private data? How can you create a sandboxed local environment using WASM and MicroPython? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

5. 

   E300 · 26 Jun 2026 · 47 min

   Maintaining Your Python Developer Instincts While Using LLM Tools

   Do you feel like your Python skills are atrophying after using LLM coding tools? How do you add the right kind of friction into your coding routine to keep your developer instincts sharp? Christopher Trudeau is back on the show this week with another batch of PyCoder's Weekly articles and projects.

6. 

   E299 · 12 Jun 2026 · 40 min

   EuroPython 2026: Celebrating 25 Years

   What's happening at EuroPython 2026? The conference celebrates its 25th anniversary this year in Kraków, Poland. This week on the show, organizers Mia Bajić and Daria Linhart Grudzien join me to discuss this year's conference.

7. 

   E313 · 2 Oct 2026 · 44 min

   Python 3.15: Exploring the New Features

   Python 3.15 is (almost*) here! Christopher Trudeau and Bartosz Zaczyński return to discuss the new version. Bartosz coordinated the series of preview articles with members of the Real Python team and wrote the showcase tutorial, "Python 3.15: Cool New Features for You to Try." Christopher's video course "What's New in Python 3.15" covers the topics from the article and shows the new features in action.

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   E312 · 25 Sep 2026 · 1 hr 8 min

   Navigating AI in Open Source: Insights From Wagtail

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9. 

   E311 · 11 Sep 2026 · 47 min

   Django Developers Survey Results & Reproducible Python Builds

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10. 

    E310 · 4 Sep 2026 · 1 hr 17 min

    Performance Engineering: Profiling and Making Apps Fast by Default

    How do you plan for the performance of your Python applications? What does a performance budget entail, and where should you spend your resources? This week on the show, we speak with Den Odell about his new book "Fast by Default: Practical Performance Engineering."

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