Everything You Need To Know About Your Poop | Gut Surgeon Explains : 1533

More from The Human Upgrade: Biohacking for Longevity & Performance All episodes →

1. 

   E1538 · 17 Sep 2026 · 54 min

   How to Hack Your Smell for Memory and Longevity WHILE YOU SLEEEP! : 1538

   Dave Asprey and neurobiologist Dr. Michael Leon explore how your sense of smell influences memory, sleep, brain aging, and longevity, and why olfactory enrichment may be one of the most overlooked tools for protecting cognitive health.

2. 

   E1537 · 16 Sep 2026 · 56 min

   Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

   This episode is a wide-ranging conversation covering testosterone and hormone replacement therapy, peptides, biohacking, psychedelics and spirituality, parenting, and building a health/longevity business, with the hosts sharing personal experiences throughout.

3. 

   E1536 · 15 Sep 2026 · 56 min

   The Peptide Secrets to a Youthful Face : 1536

   Dave Asprey and Carolina Reis de Oliveira break down how senescent cells, menopause, hydration loss, and peptide science affect skin aging, and what the latest research suggests may help make skin function biologically younger.

4. 

   E1535 · 13 Sep 2026 · 12 min

   What 36 Hours Without Sugar Does to Your Body : 1535

   This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements.

5. 

   E1534 · 11 Sep 2026 · 10 min

   New Seafood Superfood, Apple Watch Health Age, Botanical Drugs, Cannabis IQ, and Blueberries : 1534

   This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat.

6. 

   E1532 · 6 Sep 2026 · 10 min

   If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532

   Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.

7. 

   E1531 · 4 Sep 2026 · 8 min

   Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin : 1531

   This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.

8. 

   E1530 · 3 Sep 2026 · 1 hr 58 min

   Jenny McCarthy | The 3 Questions You’re NEVER Supposed to Ask : 1530

   Jenny McCarthy Wahlberg joins Dave Asprey to trace her son's autism diagnosis back to a vaccine reaction and share the detox, gut-healing, and biohacking protocol that reversed it, then dives into peptides, hormone therapy, and longevity strategies for adults.

9. 

   E1529 · 1 Sep 2026 · 36 min

   3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529

   Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.

10. 

    E1528 · 30 Aug 2026 · 10 min

    7 Brain Compounds I Take For Superhuman Focus : 1528

    can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll…