The Most Important Longevity Molecule I've Ever Found : 1524

More from The Human Upgrade: Biohacking for Longevity & Performance All episodes →

1. 

   E1529 · 1 Sep 2026 · 36 min

   3 Longevity Drugs I QUIT (And the 4 I Take Instead) : 1529

   Dave Asprey breaks down why metformin, rapamycin, and statins fall short as longevity drugs, and makes the case for tadalafil, SGLT2 inhibitors, acarbose, and low dose naltrexone instead.

2. 

   E1528 · 30 Aug 2026 · 10 min

   7 Brain Compounds I Take For Superhuman Focus : 1528

   can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it work Here's a "You'll…

3. 

   E1527 · 28 Aug 2026 · 1 hr 14 min

   Change Your Morning, Change Your Life! Hal Elrod : 1527

   Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.

4. 

   E1526 · 27 Aug 2026 · 1 hr 2 min

   Learn THIS And You’ll Become Impossible To Trigger : 1526

   Jonny Miller joins Dave to unpack how nervous system mastery—interoception, self-regulation, and emotional fluidity—transforms grief, business setbacks, intuition, and relationships into sources of growth rather than reactivity.

5. 

   E1525 · 25 Aug 2026 · 1 hr 2 min

   Jim Kwik: If You're Using AI Like This, You're Killing Your Brain : 1525

   Jim Kwik joins Host Dave Asprey to reveal how AI is quietly eroding human memory and critical thinking, and shares the framework for using it to sharpen your brain instead.

6. 

   E1523 · 21 Aug 2026 · 36 min

   The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523

   Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.

7. 

   E1522 · 20 Aug 2026 · 1 hr 3 min

   The Wild New Theory of Cancer (It's GOOD For You?) : 1522

   Patrick Coles, a physicist and biochemist, makes the case that cancer tumors are the body's intentional toxin-storage vaults rather than random malignant growth, and that lowering your toxic burden, not just fighting the tumor itself, may be the real key to reversing it.

8. 

   E1521 · 18 Aug 2026 · 2 hr 47 min

   Scream Cream and Weekly Injections (Double Episode) | Gabby Reece : 1521

   Dave Asprey and Gabby Reece swap interviews on biohacking, longevity, and mitochondrial health, then pivot into a candid conversation about fame, parenting, surrender, hormones, and finding peace through purposeful pursuit rather than achievement.

9. 

   E1520 · 16 Aug 2026 · 15 min

   It's Weird, But It Turns On Your Anti-Aging Switch : 1520

   Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain…

10. 

    E1519 · 14 Aug 2026 · 11 min

    Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral GLP-1s, Endless Exercise, and more : 1519

    Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.